A randomized control trial of Hyoscine N-Butylbromide versus Lidocaine pretreatment for alleviating pain on propofol injectio

Phase 4

Completed

• Conditions: The patient was scheduled for an elective procedure under propofol-based total intravenous anesthesia (TIVA); propofol pain; hyoscine; lidocaine; tourniquet

• Registration Number: TCTR20211028005
• Lead Sponsor: Khon kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-08-31
• Study Start: 2021-10-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

1. Patients aged 18 to 60 years old,
2. ASA PS classification 1-2

Exclusion Criteria

1. Allergy to lidocaine and Hyoscine N-butylbromide
2. BMI < 18 or > 25
3. Prescribed other analgesics, antimuscarinic or anti-inflammatory drugs
4. history of chronic pain conditions
5. Difficulty in communication or pain assessment
6. Neurological disease
7. Diabetes Mellitus
8. Contraindication for hyoscine such as untreated glaucoma, gut obstruction, benign prostate hyperplasia with urinary retention, and cardiovascular disease
9. Contraindication for lidocaine such as severe bradycardia, Wolf-Parkinson-White syndrome, and other tachyarrhythmias

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
VAS pain scores After propofol injection 100-mm visual analog scale.

Secondary Outcome Measures

Name	Time	Method
Incidence of tachycardia 5 minutes after injection of intervention drugs Heart rate more than 20% from baseline,Incidence of hypotension 5 minutes after injection of intervention drug systolic blood pressure below 90 mmHg