Extracted tooth roots (rootgrafts) as autogenous transplants for localized alveolar ridge augmentation. A controlled clinical study.

Not Applicable

Conditions: localized alveolar ridge defects
K08.1
K08.2
Loss of teeth due to accident, extraction or local periodontal disease
Atrophy of edentulous alveolar ridge

Registration Number: DRKS00009586

Lead Sponsor: Poliklinik für Zahnärztliche Chirurgie und Aufnahme, Universitätsklinikum Düsseldorf

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 45

Inclusion Criteria

Insufficient bone ridge width at the recipient site for implant placement
- Sufficient bone height at the recipient site for implant placement
- extraction of non-retainable tooth/ teeth (refers to groups receiving autogenous tooth roots)
- Healthy oral mucosa, at least 3 mm keratinized mucosa

Exclusion Criteria

- Inflammatory and autoimmune disease of oral cavity
- Uncontrolled HbA1c (> 7%) in diabetes patients
- History of malignancy requiring chemotherapy or radiotherapy within the past five years
- Concurrent or previous radiotherapy of head area
- Concurrent or previous immunosuppressant, bisphosphonate or high dose corticosteroid therapy
- Smokers
- Pregnancy or lactating women

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical width of the alveolar ridge at 26 weeks (calibrated caliper)

Secondary Outcome Measures

Name	Time	Method
-Soft tissue healing at day 10, week 4, 13, 26, 26 +10 days, 26 + 10 weeks and 26 + 26 weeks (arbitrary scale)<br>-Implant Survival (yes/ no)<br>-Peri-implant indices (i.e. plaque index - PI, bleeding on probing - BOP, probing pocket depth – PD, mucosal recession - MR) at 26 + 10 weeks and 26 + 26 weeks <br>-Immunological analysis of matrixmetalloproteinase- 8 at 26 + 10 weeks and 26 + 26 weeks <br>-Microbiological analyses at 26 + 10 weeks and 26 + 26 weeks <br><br>