Effect of Probiotic supplementation on oxidative stress
Phase 3
- Conditions
- Major Depressive Disorder.
- Registration Number
- IRCT201611292394N34
- Lead Sponsor
- Vice chancellor for research, Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Inclusion Criteria:patients with Major Depressive based on DSM-IV-TR criteria that they have not used any nutritional supplements, antiinflammatory and antidepressant drugs at least 2 months prior to intervention; aged 18 to 65 years; at least score 15 on Hamilton Depression Rating Scale 17 (HDRS-17).
Exclusion Criteria
pregnancy and lactation; drug abuse within 6 months prior to intervention; psychosis; any type of severe chronic physical illness; any extreme and severe mental disorders (suicidal ideation, psychotic symptoms, symptoms of manic phase, etc); compliance rate less than% 80; consuming probiotic foods during intervention.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Catalase. Timepoint: Begining and end of intervention. Method of measurement: Colorimetry.;Homocystein. Timepoint: Begining and end of intervention. Method of measurement: ELIZA.;Oxidized -LDL. Timepoint: Begining and end of intervention. Method of measurement: ELIZA.;MDA. Timepoint: Begining and end of intervention. Method of measurement: Colorimetry.;Arylstrase activity of Paraxonase. Timepoint: Begining and end of intervention. Method of measurement: Colorimetry.;Hs-CRP. Timepoint: Begining and end of intervention. Method of measurement: ELIZA.;Fibrinogen. Timepoint: Begining and end of intervention. Method of measurement: Coagulation.
- Secondary Outcome Measures
Name Time Method Energy intake. Timepoint: Begining and end of intervention. Method of measurement: 24-hour recall.;Physical activity. Timepoint: Begining and end of intervention. Method of measurement: IPAQ questionnaire.;Side effect. Timepoint: End of forth week and end of intervention. Method of measurement: Side effect questionnaire.;Weight. Timepoint: Begining and end of intervention. Method of measurement: Scale.