Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function
- Conditions
- Cerebral Arterial Aneurysm
- Interventions
- Registration Number
- NCT02691416
- Lead Sponsor
- The Third Central Clinical College of Tianjin Medical University
- Brief Summary
The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.
- Detailed Description
intracranial aneurysm surgery may lead to regional ischemic reperfusion injury. Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats.
As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Clinical diagnosis intracranial aneurysm surgery ,
- American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ.
- severe hepatic and renal dysfunction
- coagulation disorder
- taking antioxidant perioperative period
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description propofol postconditioning propofol postconditioning 1.2mg/L propofol propofol postconditioning sevoflurane 1.2mg/L propofol sevoflurane sevoflurane 0.5%-2% sevoflurane
- Primary Outcome Measures
Name Time Method Evidences of Clinically Definite Oxidative Stress Confirmed by ELISA Kit before induction,after clamping removal ,operation ending ,1,3,7days post surgery Evidences of clinically definite oxidative stress :Superoxide dismutase activity, Hydroxyl radical
Evidences of Clinically Definite Oxidative Stress:Micronuclei before induction,clamping removal ,operation ending,1,3,7days post surgery Evidences of clinically definite oxidative stress:micronuclei confirmed by Cytokinesis-block Micronucleus Test
Evidences of Clinically Definite Oxidative Stress Confirmed by High Performance Liquid Chromatography before induction,after clamping removal ,operation ending ,1,3,7days post surgery Evidences of clinically definite oxidative stress :α- tocopherol,γ- tocopherol which was used to assess the antioxidant defense.
Evidences of Clinically Definite Oxidative Stress: Nuclear Buds before induction,clamping removal ,operation ending,1,3,7days post surgery Evidences of clinically definite oxidative stress:nuclear buds Confirmed by Cytokinesis-block Micronucleus Test
Evidences of Clinically Definite Oxidative Stress: Nucleoplasmic Bridges before induction,clamping removal ,operation ending,1,3,7days post surgery Evidences of clinically definite oxidative stress: nucleoplasmic bridges confirmed by Cytokinesis-block Micronucleus Test
Evidences of Clinically Definite Oxidative Stress Confirmed by ELISA before induction, after clamping removal,operation ending,1,3,7days post surgery Evidences of clinically definite oxidative stress:8-isoprostane,as a reliable biomarkers of lipid peroxidation
- Secondary Outcome Measures
Name Time Method Montreal Cognitive Assessment (MoCA) before induction,1,3,7days post surgery A questionnaires is used to assess the cognitive function of patients in clinical,the total range was 0-30,and 27-30 were considered as normal value,\<27 were considered as recognitive dysfunction.
Mini Mental State Examination (MMSE) before induction,1,3,7days post surgery A questionnaires is used to assess the cognitive function of patients in clinical,the total range was 0-30,and 27-30 were considered as normal value,\<27 were considered as recognitive dysfunction.
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