Epidemiologic and Clinical Characteristics of Optic Neuritis in China
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Visual Acuity
研究概览
简要总结
This will be a hospital-based retrospective multi-center study on epidemiologic and clinical characteristics of optic neuritis among Chinese. The investigation will cover about 29 provinces or municipalities all around China.
详细描述
This national investigation will be conducted to describe the epidemiology and clinical characteristics of optic neuritis in China. All the patients will be divided into 3 groups according to the serum demyelinating antibodies (Aquaporin-4 antibody seropositive group, Myelin oligodendrocyte glycoprotein antibody seropositive group and double seronegative group). The investigator will analyze the differences among the three groups.
Primary outcomes:
-
To dig out the different visual acuity (VA, LogMAR) prognosis among the three groups;
-
To calculate the annual relapse rate (ARR) differences among the three groups (relapse times in all the follow-up time in each group/ follow-up time (years) in all in each group).
Secondary outcomes:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of optic neuritis
- •The patients' medical records were complete
排除标准
- •Patients with unclear diagnosis of optic neuritis
- •Incomplete medical records
结局指标
主要结局
Visual Acuity
时间窗: At least 1 year from the attack to the final visit
Last visual acuity records in the hospital
Annual Relapse Rate
时间窗: At least 1 year from the attack to the final visit
Calculated annual relapse rate of different subgroups in the cohort
次要结局
- Clinical characteristics of optic neuritis(At least 1 year from the attack to the final visit)
- Orbit or Brain MRI at the attack(At least 1 year from the attack to the final visit)
- Optical Coherence Tomography(At least 1 year from the attack to the final visit)
- Epidemiologic characteristics of optic neuritis(At least 1 year from the attack to the final visit)
研究者
Wei Shihui
Professor
Chinese PLA General Hospital