The Interaction Between Oxytocin and Serotonin on the Social-reward Brain Networks and Decision Making
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Changes in brain neural activity during the social reward processing as assessed via fMRI
研究概览
简要总结
The primary objective of this study is to identify any interaction between oxytocin and serotonin on neural and behavioral activity related to social reward and decision making by a double-blind, placebo-controlled, between-subject, pharmacological fMRI design
详细描述
Serotonin and oxytocin have been proved to play an important role in social reward processing and decision making in human. The aim of this study is to determine whether they interact in those essential human behaviors by a double-blind, placebo-controlled, between-subject, pharmacological fMRI design, in which 4 groups of healthy males will be administered with a random combination of nasal oxytocin (24 international units, IU) or placebo and acute tryptophan depletion (ATD, 75.2g) or placebo (a tryptophan-balanced mixture, 78.2g). The social-reward related neural activity and behavior will be assessed by a series of social reward task in and out of fMRI scanner and the decision making will be assessed by reversal learning task, ultimatum game (UG) and loss aversion task. The interaction between serotonin and oxytocin on brain networks will also be tested by resting state.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorders
- •Right-handedness
排除标准
- •History of head injury;
- •Medical or psychiatric illness.
- •High blood pressure, general cardio-vascular alterations
- •History of drug or alcohol abuse or addiction.
- •Allergy against medications or general strong allergies
- •Sleep disorders.
- •Visual or motor impairments
研究组 & 干预措施
male oxytocin and ATD group
male subjects receiving oxytocin and ATD treatment
干预措施: ATD treatment (Drug)
male oxytocin and placebo group
male subjects receiving oxytocin and ATD-placebo treatment
干预措施: oxytocin nasal spray (Drug)
male oxytocin and ATD group
male subjects receiving oxytocin and ATD treatment
干预措施: oxytocin nasal spray (Drug)
male oxytocin and placebo group
male subjects receiving oxytocin and ATD-placebo treatment
干预措施: oral placebo treatment (placebo-control for ATD) (Drug)
male placebo and ATD group
male subjects receiving oxytocin placebo and ATD treatment
干预措施: ATD treatment (Drug)
male placebo and ATD group
male subjects receiving oxytocin placebo and ATD treatment
干预措施: intranasal placebo treatment (placebo-control for oxytocin) (Drug)
male placebo group
male subjects receiving oxytocin placebo and ATD placebo treatment
干预措施: intranasal placebo treatment (placebo-control for oxytocin) (Drug)
male placebo group
male subjects receiving oxytocin placebo and ATD placebo treatment
干预措施: oral placebo treatment (placebo-control for ATD) (Drug)
结局指标
主要结局
Changes in brain neural activity during the social reward processing as assessed via fMRI
时间窗: approximately 45 minutes after intranasal administration of oxytocin, or placebo, approximately 5.5h after administration of ATD, or placebo
Whole brain and region of interest (ROI) regression analysis will be used to compare the neural activity of participants in response to social reward task in different treatment groups.
Changes in the resting state as assessed via fMRI
时间窗: Time Frame: approximately 45 minutes after intranasal administration of oxytocin, or placebo, approximately 5.5h after administration of ATD, or placebo
Resting state activity in the social reward related and decision making brain networks will be compared between the treatment groups
次要结局
- Behavioral performance in social reward related task(approximately 105 minutes after intranasal administration of oxytocin, or placebo, approximately 6.5h after administration of ATD, or placebo)
- Associations with Personalities of subjects(before 30mins ATD or placebo administration)
- Behavioral performance in decision making task(approximately 4h after administration of ATD, or placebo, before nasal spray)
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China