Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Not Applicable
Completed
- Conditions
- Insulin ResistanceAzoospermiaOligospermia
- Interventions
- Other: Blood samples
- Registration Number
- NCT01509482
- Lead Sponsor
- The Egyptian IVF-ET Center
- Brief Summary
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
- Detailed Description
During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 100
Inclusion Criteria
- sperm count less than 10 million per milliliter
- non-obstructive azoospermia
Exclusion Criteria
- high FSH ( > 10 mIU/ ml )
- high prolactin ( > 36 mIU/ml )
- abnormal karyotype
- AZF
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description insulin resistance Blood samples unexplained oligospermia and azoospermia. Blood samples will be taken for hormonal and blood lipids analysis. Fertile males Blood samples Healthy Men with proven fertility. Blood samples will be taken for hormonal and blood lipids analysis
- Primary Outcome Measures
Name Time Method serum insulin one month
- Secondary Outcome Measures
Name Time Method Fasting Glucose one month cholesterol one month high density lipoprotein ( HDL) one month Low density lipoprotein ( LDL ) one month testosterone one month Triglycerides One month
Trial Locations
- Locations (1)
The Egyptian IVF-ET center
🇪🇬Cairo, Egypt