Mapping of Electrical Properties in the Brain
- Conditions
- Malignant Glioma
- Interventions
- Other: Non-Interventional Study
- Registration Number
- NCT06470711
- Lead Sponsor
- Mayo Clinic
- Brief Summary
This study evaluates imaging methods for monitoring neural and electrical activity in the brain for improving clinical diagnosis.
- Detailed Description
PRIMARY OBJECTIVES:
I. Optimize pulse sequence acquisitions for diffusion imaging on clinical MRI vendor systems.
II. Develop image-based MRI models (including diffusion-based MRI) that accurately depict the multi-regional electrical properties in the brain (e.g., resistivity, current) to inform of neural integrity and function (including white matter tract integrity) in diseased and non-diseased states.
III. Compare/correlate image-based MRI models (e.g., diffusion) with existing structural, physiologic, and functional MRI methods (e.g., tensor imaging, fMRI, DSC-MRI, etc).
IV. Validate image-based models/measurements with loco-regional benchmarks including (but not exclusive to) electrophysiologic monitoring, functional and structural tissue assays (from available biopsies), and correlative clinical features (e.g., histology, outcomes, treatment, etc).
OUTLINE: This is an observational study.
Participants complete a survey and undergo MRI on study.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
- Aim 1: normal healthy volunteers
- Aim 2, 3, 4: participants included in IRB 16-002424, including those that have undergone surgical biopsy/resection for suspected or known glioma
- Healthy volunteer unable to have an MRI
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Observational Non-Interventional Study Participants complete a survey and undergo MRI on study.
- Primary Outcome Measures
Name Time Method Identify diffusion MRI metrics [using conductivity tensor imaging (CTI)] that inform of regional electrical properties in the brain Baseline At least 4 normal white matter regions of the brain will be analyzed. Fractional anisotropy (FA) and optimized diagnostic imaging (ODI) values will be compared to determine alignment within normal healthy white matter tracts (e.g. cortical spinal tract, corpus callosum).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mayo Clinic in Arizona
🇺🇸Scottsdale, Arizona, United States