Defense mechanisms evaluation in abstinent smokers
Not Applicable
- Conditions
- SmokingF01.145.466.753
- Registration Number
- RBR-6rzhnh
- Lead Sponsor
- Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Smokers with at least 20 years of smoking; both sexes; apparently healthy; enrolled in the Smoking Cessation Programme from Faculty of Sciences and Technology of São Paulo State University
Exclusion Criteria
Diagnosis cystic fibrosis, bronchiectasis, immotile cilia syndrome, chronic obstructive pulmonary disease, smoking-related diseases, history of nasal surgery or trauma
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It was expected that after one month of smoking abstinence, there was improvement in mucociliary clearance, as measured by the saccharin transit time test, and reduction in local and systemic inflammatory conditions, measured by inflammatory markers (TNFalfa, IL6, IL8, IL10) in nasal lavage and blood serum.;When the variables behavior after 30 days of smoking abstinence were compared, it was found that abstinent smokers presented improvement of mucociliary clearance and blood serum TNFalfa concentrations.<br>There was no difference in the behavior of inflammatory markers IL6, IL8 and IL10 in nasal lavage and blood serum, as well as TNFalpha in nasal lavage.
- Secondary Outcome Measures
Name Time Method As well as improvement in mucociliary clearance and inflammatory condition of the patients who stopped smoking, it was expected that the concentrations of carbon monoxide in exhaled air (exCO) and in blood (HbCO) also diminished.;exCO and HbCO (carboxyhemoglobin) decreased in abstinent group in relation to current smokers.