Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA

Not Applicable

• Conditions: MRSA/ MSSA Colonization of the Nares
• Interventions: Drug: 5% Povidone-Iodine USP swabs; Drug: Saline; Drug: Povidone-Iodine

• Registration Number: NCT02652325
• Lead Sponsor: Rothman Institute Orthopaedics

Brief Summary

To determine if routinely available 10% povidone-iodine swabs are more effective than saline and 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP for decolonizing MRSA.

Detailed Description

Not available

Study Timeline

• Status Verified: 2016-01
• Study First Submitted: 2016-01-06
• Study First Submitted QC: 2016-01-08
• Last Update Submitted: 2016-01-08
• Study First Posted: 2016-01-11
• Last Update Posted: 2016-01-11
• Primary Completion: 2016-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. All potential total hip and total knee arthroplasty candidates
2. All femoroacetabular osteoplasty patients
3. All pelvic acetabular osteotomy patients
4. All core decompression patients

Exclusion Criteria

1. Any trauma patients
2. Any tumor patients
3. Any patient with periprosthetic joint infection
4. Any patient with surgical site infection
5. Any patient with known MRSA infection
6. Any patients allergic to povidone-iodine
7. Patients with thyroid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP swabs	5% Povidone-Iodine USP swabs	-
Saline	Saline	-
povidone-iodine	Povidone-Iodine	-

Primary Outcome Measures

Name	Time	Method
MSSA/MRSA colonization as tested by PCR	24 hours	Subjects will undergo a swab of their nares to undergo PCR analysis to determine if they are effectively decolonized four hours after initial treatment
MSSA/MRSA colonization in the nares	4 hours	Subjects will undergo a swab of their nares to undergo PCR analysis to determine if they are effectively decolonized four hours after initial treatment