Prone positioning and Anterior chEsT wall loading to Homogenize vEntilation distRibution In aCute respiratory distress syndrome patients

Not Applicable

Recruiting

• Conditions: J80; Adult respiratory distress syndrome

• Registration Number: DRKS00033339
• Lead Sponsor: niversitätsmedizin Mannheim

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Moderate to severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 =150 mmHg

Exclusion Criteria

Age < 18 years, contraindications to prone positioning, pregnancy, presence of a cardiac pacemaker and/or implanted defibrillator, and life expectancy < 24 hours.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ung total elastic power and its components (elastic static and elastic dynamic power) normalized to end-expiratory lung volume.<br>Measurements will be performed in supine positioning, in prone positioning, following 16 hours of prone positioning and 1 hour after the transfer to supine positioning.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoints are the effects of prone positioning and anterior chest wall loading on partitioned respiratory system mechanics (lung and chest wall), end-expiratory lung volume, pulmonary ventilation and perfusion distribution, hemodynamics, gas-exchange, and serum biomarkers.