Variation in biochemical parameters in COVID-19 infection

Not yet recruiting

• Conditions: Coronavirus as the cause of diseases classified elsewhere,

• Registration Number: CTRI/2020/09/028069
• Lead Sponsor: Sri Ramachandra Institute of Higher Education Research Institute SRIHERDU

Brief Summary

In this pandemic crisis, laboratory biomarkers playa vital role in screening and in monitoring the prognosis of the disease. By evaluating the levels of the enzyme markers& inflammatory markers levels in COVID – 19 patient helps us to understandthe biochemical alterations and prognosis of the COVID – 19 pandemic infection.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-10
• Last Update Posted: 2020-09-23

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

oData of Individuals tested with Positive RT- PCR/ viral nucleic acid test for COVID-19 will be accessed oPatients Presenting with mild / No symptoms (Isolation ward participants data will be accessed) oPatients Presenting with moderate/ severe symptoms of COVID – 19 (ICU participants data will be accessed).

Exclusion Criteria

• Following Records of investigations will not be accessed: oData of Individuals with Liver disease, Rheumatoid arthritis, Renal disease & cardiac disease will not be accessed.
• oReports presenting with any other bacterial infections will not be accessed oReports of Pregnant women and age below <18 year’s will not be considered.
• oData of Patients presenting with dengue, malaria infections will not be acquired.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To understand the biochemical alterations and prognosis of the COVID – 19 pandemic infection	6 - 7 months

Secondary Outcome Measures

Name	Time	Method
Elevated LDH values were associated with 6- fold increased odds of severe COVID-19 infection. Hyper ferritinemia directly contributes to immune-suppressive and pro-inflammatory effects, and contributing to the cytokine storm and increased severity of the disease. Higher levels of hs-CRP can be a predictive marker in determining inflammatory response in COVID – 19.	6 - 7 months

Trial Locations

Locations (1)

Sri Ramachandra Medical College and Research Institute, SRIHER(DU); 🇮🇳 Kancheepuram, TAMIL NADU, India

Sri Ramachandra Medical College and Research Institute, SRIHER(DU)

🇮🇳Kancheepuram, TAMIL NADU, India

Dr K sowmya

Principal investigator

9600085116

ksowmya@sriramachandra.edu.in