Effect of non-steroidal anti-inflammatory drugs external patch for Knee Osteoarthritis; An Open label Randomized Controlled Trial.
- Conditions
- Knee Osteoarthritis
- Registration Number
- JPRN-C000000283
- Lead Sponsor
- The Japanese Society for Musculoskeletal Rehabilitation
- Brief Summary
ocal application of a plaster with non- steroidal anti-inflammatory drugs (NSAIDs) leads to the same level of improvement for knee osteoarthritis in Japanese as oral NSAIDs. Doi T, Akai M, Fujino K, et al.: Effect of non-steroidal anti-inflammatory drug plasters for knee osteoarthritis in Japanese: A randomized controlled trial. Modern Rheumatology 20(1): 24-33, 2010
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 300
Not provided
(1) Patients who had treatment for their knee at other hospital or clinic, i.e., who received therapeutic exercise, intraarticular injection, or NSAIDs within 4 weeks before the day of agreement to enter the trial. (2) Patients who had done or planned operation against the knee within 6 months before or after the day of agreement to enter the trial. (3) Patients who require intraarticular injection. (4) Patients who require aspiration of joint fluid. (5) Patients who have diseases requiring regular or intermittent use of steroid or non-steroidal anti-inflammatory drugs. (6) Patients who have articular cartilage injury or history of damage due to obvious trauma or septic arthritis. (7) Patients who were diagnosed as rheumatoid arthritis, gout, pseudogout, or collagen diseases. (8) Patients who had some difficulty to fill up their treatment diary. (9) Patients with cardiac dysfunction. (10) Patients with liver dysfunction. (11) Patients with renal dysfunction. (12) Patients with peptic ulcer. (13)Patients who had a history of bronchial asthma (Aspirin asthma, etc). (14) Patients who had a history of Anaphylaxis for NSAIDs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional assessment including ADL: JKOM Assessment of utility and safety.
- Secondary Outcome Measures
Name Time Method Assessment of pain: VAS. Assessment of adverse event in the trial period.