Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema
- Registration Number
- NCT00570544
- Lead Sponsor
- Gelb, Arthur F., M.D.
- Brief Summary
To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.
- Detailed Description
We will analyze post hoc, data that was previously published: Gelb AF et al.Chest 2006;131:690-695. We have shown that tiotropium increases resting inspiratory capacity thereby providing lung volume protection against metronome paced hyperventilation induced dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb AF et al:Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic hyperinflation with extent of lung CT scored emphysema.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 29
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 1 tiotropium patients with moderate to severe copd with varying extent of emphysema
- Primary Outcome Measures
Name Time Method Correlate tiotropium induced increase in inspiratory capacity (IC)and FEV 1 with extent of emphysema as scored by lung CT. After 30 days and 1.5hr of tiotropium
- Secondary Outcome Measures
Name Time Method Correlate decrease in IC and FEV 1 following dynamic hyperinflation with underlying emphysema. After 30 days and 1.5hr of tiotropium
Trial Locations
- Locations (1)
Arthur F Gelb Medical Corporation
🇺🇸Lakewood, California, United States