Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure

Not Applicable

• Conditions: Hypertension,Essential; Exercise Activity
• Interventions: Other: 24h-Ambulatory Blood Pressure

• Registration Number: NCT04103411
• Lead Sponsor: Anil Nigam

Brief Summary

The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-26
• Status Verified: 2019-09
• Study First Submitted: 2019-09-18
• Study First Submitted QC: 2019-09-23
• Last Update Submitted: 2019-09-23
• Study First Posted: 2019-09-25
• Last Update Posted: 2019-09-25
• Primary Completion: 2021-06-01
• Study Completion: 2022-01-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Age at consent ≥ 60 years;
2. Systolic Blood pressure measured through BPtru™ between SBP ≥ 120 mmHg and < 140 and or DBP ≥ 80 mmHg
3. Being able to sign the informed consent form

Exclusion Criteria

1. Considered "highly active" according to the International Physical Activity Questionnaire
2. Practicing more than 20 min per week of High-Intensity Interval Training
3. Use of antihypertensive medication
4. Contraindication for the practice of intense physical activity
5. Functional limitations related to the exercise test and to intensive training
6. Cardiovascular pathology
7. Atrial fibrillation
8. Psychiatric or neurological disorder
9. Renal failure
10. MMSE score < 26
11. Persons benefiting of enhanced protection: persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and patients in emergency situations.
12. Diabetes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HydroChloroThiazide	24h-Ambulatory Blood Pressure	For this group, participants have to take a diuretic (12,5 mg of Hydrochlorothiazide) daily prescribed by the doctor of this study, for twelve weeks. Participants should also maintain the same lifestyle habits that they had before the study.
High Intensity Interval Training (HIIT)	24h-Ambulatory Blood Pressure	For the twelve weeks of intervention, participants will have three training sessions per week. Each session will be done on a cycle ergometer and will last approximately 40 minutes. Participants will be supervised by certified kinesiologists and their training programs will be revised every four weeks.

Primary Outcome Measures

Name	Time	Method
24h-Ambulatory Blood Pressure	At baseline and after twelve weeks of intervention	The 24-hour ambulatory measure of the blood pressure (AMBP)

Secondary Outcome Measures

Name	Time	Method
Cardiovascular evaluation	Before and after twelve weeks of intervention	Maximum incremental cardiopulmonary exercise test (VO2MAX)
Cognitive functions	Before and after twelve weeks of intervention	Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. The investigators will measure change of score to the cognitive tests.
Flow Mediated Dilatation (FMD)	Before and after twelve weeks of intervention	Percentage of dilatation of the brachial artery

Trial Locations

Locations (1)

Cardiovascular Prevention and Rehabilitation Center; 🇨🇦 Montreal, Quebec, Canada