Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort

Completed

• Conditions: Retinal Vascular Disorder; Sport Injury
• Interventions: Diagnostic Test: Color retinography; Diagnostic Test: OCT-A; Diagnostic Test: Blood pressure measurement

• Registration Number: NCT03864380
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

The cardiovascular parameters of prolonged physical exercice have been studied, but very little data is available about the retinal vascularization.

The eye allows in vivo visualization of micro-vascularisation and is considered as an excellent marker of general vascular condition.

The marathon is an intense and prolonged exercise (running 42.195 km) in aerobic environment. Thus the investigators propose to study the vascular parameters of the retina, before and after this physical exercise.

This will allow : 1) to collect information on the physiology of the retinal vascularization to prolonged effort, 2) to detect any retinal damage (haemorrhages, edema, occlusion ...), not known to date.

The results may highlight vascular effects related to retinal hypoxia (venous tortuosity, haemorrhage, venous occlusion, hypoxic edema). Furthermore the results may urge prevention in this sport more and more democratized.

the investigators hypothesized that prolonged physical exercice causes a change in retinal vascularization.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-03-04
• Study First Submitted QC: 2019-03-05
• Study First Posted: 2019-03-06
• Study Start: 2019-03-15
• Primary Completion: 2019-04-14
• Status Verified: 2019-05
• Study Completion: 2019-05-06
• Last Update Submitted: 2019-05-06
• Last Update Posted: 2019-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Person registered at the 2019 Paris Marathon

Exclusion Criteria

• Ophthalmological disorders making access to the fundus impossible for both eyes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Person running a marathon	OCT-A	Exams performed before (1 month maximum) and after the marathon (1 hour maximum) : Color retinography Optical Coherence Tomography - Angiography (OCT-A) Blood pressure measurement
Person running a marathon	Color retinography	Exams performed before (1 month maximum) and after the marathon (1 hour maximum) : Color retinography Optical Coherence Tomography - Angiography (OCT-A) Blood pressure measurement
Person running a marathon	Blood pressure measurement	Exams performed before (1 month maximum) and after the marathon (1 hour maximum) : Color retinography Optical Coherence Tomography - Angiography (OCT-A) Blood pressure measurement

Primary Outcome Measures

Name	Time	Method
Density of retinal vascular plexuses	up to 1 hour	Percentage, Measurement with OCT-A

Trial Locations

Locations (1)

Fondation A de Rothschild; 🇫🇷 Paris, France