An additional rescue dose of GnRH antagonist administered the day before hCG trigger is effective to prevent ovarian hyperstimulation syndrome (OHSS) in IVF/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes

Not Applicable

Completed

• Conditions: Ovarian hyperstimulation syndrome (OHSS), ovarian stimulation, GnRH antagonist, IVF; Pregnancy and Childbirth

• Registration Number: ISRCTN02750360
• Lead Sponsor: IAKENTRO (Greece)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-13
• Last Update Posted: 20 November 2017

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 194

Inclusion Criteria

1. Patients age 18-40 years, at high risk for OHSS who underwent ovarian stimulation for in vitro fertilization (IVF) using the 6th day fixed GnRH antagonist protocol. Patients were considered at actual risk of developing moderate to severe OHSS when they had a high or rapidly rising serum estradiol (=3500 pg/ml before oocyte maturation and projected to be >4500 pg/ml the day of hCG administration) and 18 or more follicles =11 mm but without any mature follicle >16 mm appearing at that time.
2. With polycystic ovaries (The Rotterdam ESHRE/ASRM-sponsored PCOS consensus Workshop Group, 2004)
3. At high risk for OHSS
4. Not willing to cancel their IVF cycle

Exclusion Criteria

Polycystic ovarian syndrome (PCOS) patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified