The Effect of Local Injection of Botulinum Toxin in Parkinson's Patients
- Conditions
- Parkinson's Disease.Parkinson's disease
- Registration Number
- IRCT20100127003217N11
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 35
Patients with idiopathic or familial Parkinson's disease (Parkinson's disease or PD); age between 30 to 85 years, one year after definitive diagnosis; patients with PD who have hand tremor (single-sided or bilateral).
Patients with PD who are in stages I-III of Hoehn & Yahr staging .
Patients with PD who are being treated with routine anti-Parkinson drugs, especially levodopa.
Patients with PD who are willing to participate in the study and are satisfied with botulinum toxin injections.
Patients with PD who have had cognitive impairment or psychosis
Patients with PD who have had a history of botulinum Toxin injection or any other injection over the past four months
Patients with PD who have had a history of surgery (DBS: deep brain stimulation)
Patients with secondary Parkinsonism, such as Pharmaceutical Parkinsonism
Patients with hand tremor which is resulting from a medical condition, such as antipsychotic drugs
Pregnancy and breastfeeding
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical severity of hand tremor. Timepoint: At the beginning of the study and before the intervention, 1.5 months, 4 months after injection. Method of measurement: 2 questionnaires including FTM (Fahn_Tolosa_Marin Temor Rating Scale) and UPDRS (Unified Parkinsone Disease Rating Scale).
- Secondary Outcome Measures
Name Time Method Functional severity of hand tremor. Timepoint: At the beginning of the study and before the intervention, 1.5 months, 4 months after injection. Method of measurement: ADL questionnaire from Bain and Findley questionnaire, manual dynamometer, 10 euro coin test.