The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients
Completed
- Conditions
- Type 2 Diabetes
- Registration Number
- NCT01127997
- Lead Sponsor
- The Catholic University of Korea
- Brief Summary
Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- age 35-70
- HbA1c 6-8%
- DM duration less than 5 yrs
Exclusion Criteria
- type 1 DM, secondary DM, gestational DM
- patients using insulin, TZDs
- patients using corticosteroid, herb medication or other medications affecting glucose tolerance
- renal dysfunction (Cr > 1.5mg/dL)
- hepatic dysfunction (LFT > x 3UNL)
- anemia (Hg < 10g/dL)
- ischemic heart disease, congestive heart failure
- severe diabetic complication (CRF, CVA, PDR, gastroparesis)
- infectious disease
- malignancy
- pregnant women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Area under the curve of plasma glucose after meal 3 months Compare the post-lunch AUC of glucose between two meal tolerance tests(one after having breakfast, one after not having breakfast)
- Secondary Outcome Measures
Name Time Method the mechanism of second-meal phenomenon 3 months serum FFA, plasma insulin, C-peptide, incretin concentration will be measured
Trial Locations
- Locations (1)
St. Vincent's hospital
🇰🇷Suwon, Kyounggi-do, Korea, Republic of