Effects of 25-hydroxyvitamin D on dental implant osseointegration in type 2 diabetes mellitus

Recruiting

• Conditions: Type 2 Diabetes mellitus Vitamin D Insufficiency; Type 2 Diabetes mellitus; Vitamin D Insufficiency

• Registration Number: TCTR20230727002
• Lead Sponsor: Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-27
• Last Update Posted: 19 August 2024
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Healthy patient or patient diagnosed with type 2 diabetes mellitus with edentulous site with adequate bone dimensions for dental implant placement
2. The implant sites are required to have at least 4 months of healing post-extraction, with no previous ridge augmentation or bone grafting

Exclusion Criteria

1. Systemic diseases that may affect wound healing
2. Cancer
3. Bone metabolic disease such as osteoporosis
4. Under treatment using bisphosphonate
5. Regular use of medications that could affect healing
6. Irradiation in head and neck area
7. Untreated periodontal disease
8. Smoking habit
9. Pregnancy or lactation, planned pregnancy
10. Immunocompromised or under immunosuppressive drug treatment
11. Addiction to alcohol or drugs
12. History of kidney stones
13. Abnormal sensitivity to vitamin D or hypervitaminosis D

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Marginal bone loss at 1,3,6,9 and 12 months follow-up mm

Secondary Outcome Measures

Name	Time	Method
Implant stability at 3 months follow-up ISQ value,Bone-related biological marker and inflammatory cytokines 1,2,3,6 and 12 months follow-up pg/ml