A Study of Lebrikizumab in Participants With Uncontrolled Asthma on Inhaled Corticosteroids and a Second Controller Medication
- Registration Number
- NCT01868061
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of lebrikizumab in participants with asthma whose disease remains uncontrolled despite daily treatment with inhaled corticosteroid (ICS) therapy and at least one second controller medication. Participants will be randomized in 1:1:1 ratio to receive double-blind treatment with either lebrikizumab ("high" or "low") or placebo, administered as subcutaneous (SC) injection every 4 weeks for 52 weeks, in addition to their standard-of-care therapy. This will be followed by a 52-week double-blind active treatment extension. Participants who were assigned to placebo during the placebo-controlled period of the trial will be re-randomized at Week 52 to receive blinded SC lebrikizumab 37.5 milligrams (mg) or 125 mg every 4 weeks from Weeks 53 to 104. The anticipated time on study treatment is 104 weeks. After study treatment, all participants will complete a 20-week safety follow-up.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1068
- Asthma diagnosis for greater than equal to (>/=) 12 months at Visit 1
- Bronchodilator response at Visit 1, 2, or 3
- Pre-bronchodilator FEV1 of 40 percent (%) - 80% predicted at both Visits 2 and 3
- On ICS therapy at a total daily dose of 500-2000 microgram (mcg) of fluticasone propionate dry powder inhaler (DPI) or equivalent for >/= 6 months prior to Visit 1
- On an eligible second controller medication (long-acting Beta-agonist [LABA], leukotriene receptor antagonist [LTRA], long-acting muscarinic antagonist [LAMA], or theophylline) for 6 months prior to Visit 1
- Uncontrolled asthma at Visit 1 and/or Visit 2, and at Visit 3
- Chest X-ray or computed tomography (CT) scan within 3 months prior to Visit 1 or chest X-ray during the screening period (prior to Visit 3) confirming the absence of other clinically significant lung disease
- Demonstrated adherence with controller medication during the screening period
- History of severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the lebrikizumab injection
- Maintenance oral corticosteroid therapy within 3 months of Visit 1
- Treatment with systemic (oral, intravenous [IV], or intramuscular [IM]) corticosteroids within 4 weeks prior to Visit 1 or during the screening period
- Treatment with intra-articular corticosteroids within 4 weeks prior to Visit 1 or during the screening period or anticipated need for intra-articular corticosteroids during the course of the study
- Infection requiring hospital admission for >/=24 hours or requiring treatment with IV or IM antibiotics within 4 weeks prior to Visit 1 or during screening; Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening; Active parasitic infection or Listeria monocytogenes infection within 6 months prior to Visit 1 or during screening
- Active tuberculosis requiring treatment within 12 months prior to Visit 1
- Known immunodeficiency, including, but not limited to, human immunodeficiency virus (HIV) infection
- Evidence of acute or chronic hepatitis or known liver cirrhosis
- History of interstitial lung disease, chronic obstructive pulmonary disease (COPD), or other clinically significant lung disease other than asthma
- Known current malignancy or current evaluation for potential malignancy
- Current smoker or former smoker with a history of greater than (>) 10 pack-years
- History of alcohol or drug abuse
- Past and/or current use of any anti-interleukin (IL)-13 or anti-IL-4/IL-13 therapy, including lebrikizumab; use of other monoclonal antibody therapy, including omalizumab, within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) or during screening
- Initiation of or change in allergen immunotherapy within 3 months prior to Visit 1 or during screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period. Lebrikizumab (37.5 mg) Lebrikizumab Participants will receive SC injection of lebrikizumab (37.5 mg) every 4 weeks for 104 weeks. Lebrikizumab (125 mg) Lebrikizumab Participants will receive SC injection of lebrikizumab (125 mg) every 4 weeks for 104 weeks. Placebo Lebrikizumab Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period.
- Primary Outcome Measures
Name Time Method Rate of Asthma Exacerbations During the 52-Week Placebo-Controlled Period Baseline up to Week 52
- Secondary Outcome Measures
Name Time Method Change from Baseline In Asthma Rescue Medication (Number of Puffs or Nebulized Treatments) Baseline, Week 52 Change From Baseline in Standardized Asthma Quality of Life Questionnaire (AQLQ) Score Baseline, Week 52 Change From Baseline in Asthma Control Questionnaire-5 (ACQ-5) Score Baseline, Week 52 Absolute Change From Baseline in Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) Baseline, Week 52 Time to First Asthma Exacerbation Baseline up to Week 52 Percentage of Participants With Anti-Therapeutic Antibodies to Lebrikizumab Baseline up to Week 124 (assessed at Baseline, Weeks 4, 12, 24, 36, 52, 64, 76, 92, 104, 112, and 124) Rate of Urgent Asthma-Related Urgent Health Care Utilization Baseline up to Week 52 Percentage of Participants With Adverse Events Baseline up to Week 124 Minimum Serum Concentration (Cmin) of Lebrikizumab Predose (0 hour) on Weeks 4, 12, 24, 36, and 52
Trial Locations
- Locations (232)
NZOZ Lekarze Specjalisci
🇵🇱Wroclaw, Poland
ZAPA JJ Sro
🇸🇰Levice, Slovakia
Allergy Consultants PA
🇺🇸Boca Raton, Florida, United States
Allergy and Asthma Relief Experts
🇺🇸Granada Hills, California, United States
The Allergy and Asthma Center
🇺🇸Fort Wayne, Indiana, United States
Atlanta Allergy & Asthma Clini
🇺🇸Woodstock, Georgia, United States
Integrated Research Group Inc
🇺🇸Upland, California, United States
Brookstone Clinical Res Ctr
🇺🇸Columbus, Georgia, United States
Southeast Regional Research Group
🇺🇸Columbus, Georgia, United States
Aeroallergy Research Labs
🇺🇸Savannah, Georgia, United States
Allergy & Asthma Consultants
🇺🇸Redwood City, California, United States
Allergy Associates, Inc.
🇺🇸Chesterfield, Missouri, United States
DataQuest Medical Research
🇺🇸Lawrenceville, Georgia, United States
Kern Allergy Med Clinic, Inc.
🇺🇸Bakersfield, California, United States
University of New Mexico; School of Med
🇺🇸Albuquerque, New Mexico, United States
Georgia Pollens
🇺🇸Albany, Georgia, United States
Allergy and Clinical Immunology Associates
🇺🇸Pittsburgh, Pennsylvania, United States
Greenville Pharmaceutical Research
🇺🇸Greenville, South Carolina, United States
Ordinace pro tuberkulozu a respiracni nemoci
🇨🇿Strakonice, Czechia
Penn State Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Clinical Research Center, L.L.C.
🇺🇸Saint Louis, Missouri, United States
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Winthrop Univ Hospital
🇺🇸Mineola, New York, United States
Hôpital de La Croix Rousse
🇫🇷Lyon, France
Groupe Hospitalier Cochin St Vincent de Paul La Roche Guyon
🇫🇷Paris, France
Cheema Research, Inc
🇨🇦Mississauga, Ontario, Canada
Asthma and Allergy Physicians LLC
🇺🇸Brockton, Mississippi, United States
Vital Prospects Clin Res Pc
🇺🇸Tulsa, Oklahoma, United States
Respiratory Clinical Trials Pty Ltd
🇦🇺Toorak Gardens, South Australia, Australia
Concord Repatriation General Hospital; Department Thoracic Medicine
🇦🇺Sydney, New South Wales, Australia
Thomayerova nemocnice
🇨🇿Praha 4 - Krc, Czechia
Allergy & Asthma Clin Cen TX
🇺🇸Round Rock, Texas, United States
Dr Anil Dhar Professional Medicine Corporation
🇨🇦Windsor, Ontario, Canada
Instituto de Investigaciones Clinicas-Mar del Plata
🇦🇷Buenos Aires, Argentina
Asst Santi Paolo E Carlo
🇮🇹Milano, Lombardia, Italy
Adult Pediatric Allergy Central Jersey
🇺🇸Edison, New Jersey, United States
Princess Alexandra Hospital, Department of Respiratory and Sleep Medicine
🇦🇺Brisbane, Queensland, Australia
Elliot J. Ginchansky, MD, PA
🇺🇸Dallas, Texas, United States
AusTrials
🇦🇺Brisbane, Queensland, Australia
Medical Center Tara OOD
🇧🇬Veliko Tarnovo, Bulgaria
Centre Hospitalier Universitaire de Bicêtre
🇫🇷Le Kremlin-bicêtre, France
Medaimun GmbH
🇩🇪Frankfurt am Main, Germany
Upstate Pharmaceutical Research; Greenville
🇺🇸Greenville, South Carolina, United States
Praxis Dr. med. Hermann A. Trauth
🇩🇪Marburg, Germany
Ottawa Allergy Research Corp
🇨🇦Ottawa, Ontario, Canada
Manna Research
🇨🇦Toronto, Ontario, Canada
Allergy Associates of Utah
🇺🇸Murray, Utah, United States
KASMED, s.r.o.; Alergologie a klinicka imunologie
🇨🇿Tabor, Czechia
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Ewha Womans University Medical Center
🇰🇷Seoul, Korea, Republic of
Pneumologisches Forschungsinstitut
🇩🇪Großhansdorf, Germany
Fukuoka National Hospital
🇯🇵Fukuoka, Japan
Ibarakihigashi National Hospital
🇯🇵Ibaraki, Japan
Yokohama City University Medical Center; Neurology
🇯🇵Kanagawa, Japan
Greenlane Clinical Centre
🇳🇿Auckland, New Zealand
Kumamoto Saishunso National Hospital
🇯🇵Koshi-shi, Japan
Kyoto University Hospital, Respiratory Medicine
🇯🇵Kyoto, Japan
Machida Municipal Hospital
🇯🇵Machida-shi, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Seoul St Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Medical Research Inst. of New Zealand; Respiratory
🇳🇿Wellington, New Zealand
Nagoya Ekisaikai Hospital
🇯🇵Nagoya-shi, Japan
Hospital Nacional Luis N Saenz PNP
🇵🇪Lima, Peru
ABK Reuma SRL- Medicentro BioCiencias
🇵🇪Lima, Peru
Clinica San Pablo
🇵🇪Lima, Peru
Tohoku Medical and Pharmaceutical University Wakabayashi Hospital
🇯🇵Sendai-shi, Japan
Takamatsu Municipal Hospital
🇯🇵Takamatsu-shi, Japan
Nihon University Itabashi Hospital
🇯🇵Tokyo, Japan
Clinica Internacional
🇵🇪Lima, Peru
Instituto Peruano de Investigacion en Ciencias Medicas
🇵🇪Lima, Peru
Clinica San Borja
🇵🇪Lima, Peru
Canterbury Respiratory Research Group; Respiratory
🇳🇿Christchurch, New Zealand
Complexo Hospitalario Universitario de Santiago CHUS - Hospital de Conxo
🇪🇸Santiago de Compostela, La Coruña, Spain
Seoul National University Hospital; Division of Allergy and Clinical Immunology
🇰🇷Seoul, Korea, Republic of
Centro de Investigación Ricardo Palma
🇵🇪Lima, Peru
GRAŻYNA JASIENIAK-PINIS ATOPIA Niepubliczny Zakład Opieki Zdrowotnej Poradnie Specjalistyczne
🇵🇱Krakow, Poland
Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital
🇷🇴Timisoara, Romania
Ryazan Regional Clinincal Cardiology Dispensary
🇷🇺Ryazan, Russian Federation
Hospital Universitario la Paz; Servicio de Alergologia
🇪🇸Madrid, Spain
Raigmore Hospital
🇬🇧Inverness, United Kingdom
Respiratory Research Unit
🇿🇦Cape Town, South Africa
St.Petersburg State Budget Healthcare Institution City Hospital of Saint Venerable Martyr Elizabeth
🇷🇺St. Petersburg, Russian Federation
City Hospital #40 of Resort Administrative District
🇷🇺St. Petersburg, Russian Federation
Pneumo-Alergo Centrum s.r.o.
🇸🇰Bratislava, Slovakia
City Hospital #1
🇺🇦Mykolaiv, Ukraine
Municipal Institution Odesa Regional Clinical Hospital
🇺🇦Odesa, Ukraine
Royal Preston Hospital
🇬🇧Preston, United Kingdom
City Clinical Hospital #13
🇷🇺Moscow, Russian Federation
Aliwal Shoal Medical Center
🇿🇦Umkomaas, South Africa
Clinical Projects Research
🇿🇦Worcester, South Africa
Siberian State Medical University
🇷🇺Tomsk, Russian Federation
Donetsk Municipal Treatment and Prophylactic Institution Central City Clinical Hospital #1
🇺🇦Donetsk, Ukraine
Municipal Institution of Health Care City Clinical Hospital #13
🇺🇦Kharkiv, Ukraine
Scientific and Research Institute of Invalid Rehabilitation of Moh of Ukraine
🇺🇦Vinnytsya, Ukraine
LLC Diaservis
🇺🇦Zaporizhzhia, Ukraine
Institut Catala de Serveis Medics
🇪🇸Girona, Spain
Municipal Institution Cherkasy Regional Hospital of Cherkasy Regional Council
🇺🇦Cherkasy, Ukraine
St Augustines Hospital; Infectoilogy
🇿🇦Durban, South Africa
Limpopo Clinical Research Initiative; Tamboti Medical Centre
🇿🇦Tabazimbi, South Africa
SI National Institute of Phthisiology and Pulmonology n.a. F.G.Yanovskyi under NAMS of Ukraine
🇺🇦Kyiv, Ukraine
Municipal Institution Zaporizhzhia City Multifield Clinical Hospital #9
🇺🇦Zaporizhzhye, Ukraine
Southmead Hospital
🇬🇧Westbury-on-Trym, Bristol, United Kingdom
Research Institute of South Florida Inc
🇺🇸Miami, Florida, United States
Clinical Research Consortium
🇺🇸Las Vegas, Nevada, United States
St. Petersburg State Medical University n.a. I.P. Pavlov
🇷🇺St. Petersburg, Russian Federation
Medical Research of Arizona; Allergy, Asthma & Immu
🇺🇸Scottsdale, Arizona, United States
Southern California Institute For Respiratory
🇺🇸Los Angeles, California, United States
Allergy & Asthma Medical Group; Clinical Research Division
🇺🇸Walnut Creek, California, United States
Sarasota Clinical Research
🇺🇸Sarasota, Florida, United States
Asthma, Allergy & Sinus Center
🇺🇸Baltimore, Maryland, United States
Chesapeake Clinical Research
🇺🇸Baltimore, Maryland, United States
Howard County Center for Lung and Sleep, LLC
🇺🇸Columbia, Maryland, United States
Allergy Partners of Western NC
🇺🇸Asheville, North Carolina, United States
Allergy & Asthma Centre of Dayton
🇺🇸Centerville, Ohio, United States
Asthma and Allergy Research Associates
🇺🇸Upland, Pennsylvania, United States
EPIMRD, Inc. DBA Western Sky Medical Research
🇺🇸El Paso, Texas, United States
Baylor College of Medicine; Dept of Medicine
🇺🇸Houston, Texas, United States
University of Wisconsin;Allergy & Asthma Clinical Research
🇺🇸Madison, Wisconsin, United States
Pulmonary Research of Albingdon
🇺🇸Abingdon, Virginia, United States
Centro Modelo de Cardiologia
🇦🇷San Miguel de Tucuman, Argentina
Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov AD
🇧🇬Smolyan, Bulgaria
Multiprofile Hospital For Active Treatment prof Kirkovich
🇧🇬Stara Zagora, Bulgaria
Del Carpio Jaime Dr - Allergiste & Immunologue
🇨🇦Montreal, Quebec, Canada
Hopital Bichat Claude Bernard ; Service de Pneumologie
🇫🇷Paris, France
Selye János Kórház és Rendelőintézet; Allergológiai Szakrendelés
🇭🇺Komárom, Hungary
Rambam Health Care Campus
🇮🇱Haifa, Israel
Hadassah Medical Center; Pulmonary Institute
🇮🇱Jerusalem, Israel
Università Cattolica del Sacro Cuore UOC Allergologia- Policlinico Gemelli
🇮🇹Rome, Lazio, Italy
Banbuntane Hotokukai Hospital
🇯🇵Aichi, Japan
Iwata City Hospital
🇯🇵Shizuoka, Japan
Soonchunhyang University Bucheon Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
Centro de Investigacion Medico Biologico y Terapia Avanzada, S.C.
🇲🇽Guadalajara, Mexico
Unidad de Investigacion Clinica En Medicina (Udicem) S.C.
🇲🇽Monterrey, Mexico
P3 Research
🇳🇿Tauranga, New Zealand
Hospital Nacional Adolfo; Guevara Velasco Essalud
🇵🇪Cusco, Peru
Spitalul Clinic de Pneumoftiziologie Palazu Mare Constanta
🇷🇴Palazu Mare, Romania
Targu Mures Clinical Emergency County Hospital
🇷🇴Targu Mures, Romania
Penza Regional Clinical Hospital Named After N. N. Burdenko; Therapy Department
🇷🇺Penza, Russian Federation
Tiervalei Trial Centre
🇿🇦Cape Town, South Africa
Dr PJ Sebastian
🇿🇦Durban, South Africa
Instituto de Ciencias Medicas
🇪🇸Alicante, Spain
Hospital Universitario Virgen Macarena
🇪🇸Seville, Sevilla, Spain
Hospital Universitario Puerta de Hierro Majadahonda; Servicio de Neumología
🇪🇸Majadahonda, Madrid, Spain
MI Dnipropetrovsk clinical association of emergency care of Dnipropetrovsk regional council
🇺🇦Dnipropetrovsk, Ukraine
SI Institute of Therapy n.a. L.T. Mala of National Academy of Medical Sciences of Ukraine
🇺🇦Kharkiv, Ukraine
Royal Hallamshire Hospital; Department of Oncology
🇬🇧Sheffield, United Kingdom
Allergy & Asthma Research Center
🇺🇸San Antonio, Texas, United States
Quality Assurance Research Ctr
🇺🇸San Antonio, Texas, United States
Discovery Clinical Trials
🇺🇸San Antonio, Texas, United States
Western States Clinical Research, Inc
🇺🇸Wheat Ridge, Colorado, United States
Asthma & Allergy; Associates, P.C.
🇺🇸Colorado Springs, Colorado, United States
Storms Clinical Research; Institute
🇺🇸Colorado Springs, Colorado, United States
Cotton O'Neil Clinic; Stormont-Vail Hlth Care
🇺🇸Topeka, Kansas, United States
The Lung Institute of Western Australia; Sir Charles Gairdner Hospital
🇦🇺Nedlands, Western Australia, Australia
Clinical Research Center of Alabama, LLC
🇺🇸Birmingham, Alabama, United States
Clinical Research Inst
🇺🇸Minneapolis, Minnesota, United States
Integrity People Services Research Company
🇺🇸Oklahoma City, Oklahoma, United States
Oklahoma Institute of Allergy and Asthma Clinical Research LLC
🇺🇸Oklahoma City, Oklahoma, United States
Azienda Ospedaliera Monaldi
🇮🇹Napoli, Campania, Italy
Azienda Ospedaliera Universitaria di Modena
🇮🇹Modena, Emilia-Romagna, Italy
Fondazione IRCCS Policlinico San Matteo di Pavia; S.S. Fisiopatologia Respiratoria
🇮🇹Pavia, Lombardia, Italy
P.O. Citta' Di Sesto S. Giovanni
🇮🇹Sesto San Giovanni, Lombardia, Italy
Azienda Policlinico Vittorio Emanuele; Pneumologia Riabilitativa E Allergologia
🇮🇹Catania, Sicilia, Italy
National Jewish Health
🇺🇸Denver, Colorado, United States
Colorado Allergy & Asthma Centers, Pc
🇺🇸Denver, Colorado, United States
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
SHATPD Sveta Sofia; Clin Pulmonary Diseases
🇧🇬Sofia, Bulgaria
Chaim Sheba Medical Center; Oncology Dept
🇮🇱Ramat Gan, Israel
Hikarigaoka Spellman Hospital; Rheumatology
🇯🇵Miyagi, Japan
Consultorio Especialidad Alergologia Pediatrica
🇲🇽Villahermosa, Mexico
Specjalistyczna Poradnia Pulmonologiczna
🇵🇱Ostrow Wielkopolski, Poland
Yaroslavl State Medical Academy - Clinical Hospital #2
🇷🇺Yaroslavl, Russian Federation
Live Oak Allergy & Asthma Clinic
🇺🇸San Antonio, Texas, United States
5TH MHAT; Pulmonology
🇧🇬Sofia, Bulgaria
Medical Center for Specialized Outpatient Medical Care for Pulmonary Diseases
🇧🇬Sofia, Bulgaria
Fundacion Cidea
🇦🇷Buenos Aires, Argentina
Dr. Paul Shapero
🇺🇸Bangor, Maine, United States
Nazareth EMMS Hospital
🇮🇱Nazareth, Israel
Hiroshima Allegy & Respiratory Clinic
🇯🇵Hiroshima, Japan
Kinki University Hospital
🇯🇵Osaka, Japan
Tokyo-Eki Center-building Clinic
🇯🇵Tokyo, Japan
Diagnostic and Consulting Centre Mladost - M OOD
🇧🇬Varna, Bulgaria
Quality of Life Medical & Research Center
🇺🇸Tucson, Arizona, United States
Asthma & Allergy of Idaho
🇺🇸Twin Falls, Idaho, United States
Infinity Medical Research Inc
🇺🇸North Dartmouth, Massachusetts, United States
Alitera - Med - Medical Center EOOD
🇧🇬Sofia, Bulgaria
Sagamihara National Hospital
🇯🇵Kanagawa, Japan
Clinica los Andes
🇵🇪Miraflores, Peru
Niepubliczny Zespol Poradni Specjalistycznych PULS Poradnia Chorob Pluc i Gruzlic
🇵🇱Pila, Poland
ABC-PULMO Poradnia Chorob Pluc
🇵🇱Radom, Poland
Dobrostan Gabinety Lekarskie
🇵🇱Wroclaw, Poland
Spitalul Clinic de Pneumoftiziologie Leon Daniello Cluj-Napoca, Sectia Clinica Pneumologie I
🇷🇴Cluj-Napoca, Romania
Neem Research Group, Inc.
🇺🇸Columbia, South Carolina, United States
I.M. Sechenov Moscow State Medical University the Ministry of Health and Social Development of RF
🇷🇺Moscow, Russian Federation
CEMER Centro Médico de Enfermedades Respiratorias
🇦🇷Vicente López, Argentina
Private Practice
🇧🇪Jambes, Belgium
UZ Leuven Gasthuisberg
🇧🇪Leuven, Belgium
National Multiprofile Hospital Tsar Boris III
🇧🇬Sofia, Bulgaria
Uno Naikakokyukika Clinic
🇯🇵Isesaki-shi, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Tokyo, Japan
Alergo Medical Specjalistyczna Przychodnia Lekarska
🇵🇱Tarnow, Poland
Patrick V. Perin, MD
🇺🇸Teaneck, New Jersey, United States
Centro Respiratorio Infantil
🇦🇷Rosario, Argentina
Specialized Hospital for Active Treatment for pneumo-phtysiatric diseases
🇧🇬Ruse, Bulgaria
Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika
🇭🇺Debrecen, Hungary
Markusovszky Egyetemi Oktatokorhaz
🇭🇺Szombathely, Hungary
Toyama City Hospital
🇯🇵Toyama, Japan
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi
🇵🇱Lodz, Poland
Saratov State Medical Univ; Clinical Immun & Allerg
🇷🇺Saratov, Russian Federation
Municipal Budgetery Clinical Institution of Healthcare; NA Semashko City Hospital
🇷🇺Yaroslavl, Russian Federation
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
City Clinical Hospital No.1; Therap Ukr Med Stom Acad
🇺🇦Poltava, Ukraine
Takatsuki Red Cross Hospital; Division of Diabetes / Endocrinology / Lifestyle-Related Disease
🇯🇵Osaka, Japan
Kishiwada City Hospital
🇯🇵Osaka, Japan
Hanzomon Hospital
🇯🇵Tokyo, Japan
SP ZOZ Bienkowka- Osrodek Zdrowia w Bienkowce
🇵🇱Bieńnkówka, Poland
Centrum Medyczne Ogrodowa
🇵🇱Skierniewice, Poland
Municipal Polyclinic #25
🇷🇺St Petersburg, Russian Federation
Imunoalergologia Dzurilla s.r.o.
🇸🇰Nitra, Slovakia
Kyiv City Tuberculosis Hospital #1; Department of Differential Diagnosis of Lung Diseases
🇺🇦Kyiv, Kiev Governorate, Ukraine
Niepubliczny Zaklad Opieki Zdrowotnej PROFILAKTYKA Wladyslaw Pierzchala
🇵🇱Ruda Śląska, Poland
Lexmedica
🇵🇱Wroclaw, Poland
City Clinical Hospital #2
🇷🇺Novosibirsk, Russian Federation
Clinical Hospital Centre Zemun
🇷🇸Zemun, Serbia
Institute of Lung Diseases Vojvodina
🇷🇸Sremska Kamenica, Serbia
Yale University School Of Medicine
🇺🇸New Haven, Connecticut, United States
Center For Pharmaceutical Research
🇺🇸Kansas City, Missouri, United States
East-West Medical Research Institute
🇺🇸Honolulu, Hawaii, United States
Future Search Clinical Trials L.P.
🇺🇸Austin, Texas, United States