Hemophilia and Atherosclerotic Plaque Imaging

Completed

Conditions: atherosclerosis
hemophilia
10064477
10003216

Registration Number: NL-OMON46894

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Study population:;1. Hemophilia A or B patients
2. Males, 18 years and older
3. Presence of cardiovascular risk factors, including an age of 50 years and more;Controls:
1. Males, 18 years and older
2.. Presence of cardiovascular risk factors, including an age of 50 years and more

Exclusion Criteria

Study population and controls:
1. Symptomatic carotid atherosclerotic disease
2. History of allergic reaction to gadolinium (very rare)
3. History of claustrophobia
4. History of severe renal failure (estimated glomerular filtration rate - < 45 ml/min)
5. Presence of cardiac pacemaker;Controls:
Use of anticoagulation

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the plaque constitution in terms of intraplaque<br /><br>hemorrhage and plaque burden as measured with 3T MRI in both hemophilia<br /><br>patients and patients and controls</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are differences in endothelial wall function and plaque<br /><br>components (calcification, necrotic core) between the patient and control<br /><br>group.<br /><br><br /><br>Furthermore, the relation between plaque composition and severity of<br /><br>haemophilia and traditional cardiovascular risk factors will be analysed. </p><br>