CLIC1 in Patients Presenting PD

Completed

• Conditions: Hip Fractures; Hip Disease
• Interventions: Behavioral: Postoperative delirium; Procedure: Hip surgery

• Registration Number: NCT05446181
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-27
• Study First Submitted: 2022-07-01
• Study First Submitted QC: 2022-07-01
• Study First Posted: 2022-07-06
• Primary Completion: 2024-10-30
• Study Completion: 2024-10-30
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-24
• Last Update Posted: 2024-11-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia

Exclusion Criteria

• Patients who are unconscious
• Patients who are unable to communicate
• Alzheimer
• Parkinson Disease
• Conversion to general anesthesia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Old with postoperative delirium	Hip surgery	-
Young	Hip surgery	-
Old with postoperative delirium	Postoperative delirium	-
Old without postoperative delirium	Hip surgery	-

Primary Outcome Measures

Name	Time	Method
expression pattern of CLIC1 protein	Immediate after spinal anesthesia

Trial Locations

Locations (1)

Seoul National Univ. Bundang Hospital; 🇰🇷 Seongnam, Gyeonggi, Korea, Republic of