Protein Nutrition for Muscle Hypertrophy in Older Adults

Not Applicable

Completed

• Conditions: Anabolically Resistant Elderly Muscle; Healthy Elderly Muscle

• Registration Number: NCT02315391
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.

Detailed Description

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly

Study Timeline

• Study Start: 2012-09
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2014-11
• Study First Submitted: 2014-11-12
• Study First Submitted QC: 2014-12-10
• Study First Posted: 2014-12-11
• Last Update Submitted: 2014-12-17
• Last Update Posted: 2014-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Must habitually complete a minimum of 5000 steps per day
• Having obtained informed consent
• Non-obese
• Non-smoker

Exclusion Criteria

• Aged >80 years
• Inability to comply with study procedures
• Currently participating or having participated in another infusion trial during last 12 months
• Any acute or chronic llness
• History of neuromuscular problems
• Medications known to affect protein metabolism
• Individuals who complete fewer than 5000 steps per day
• Individuals who have metal implants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in myofibrillar fractional synthetic rate (FSR)	one day and 2 weeks

Secondary Outcome Measures

Name	Time	Method
change in non-myofibrillar fractional synthetic rate (FSR)	baseline and one day of feeding
Capillary dilatation and blood flow	2 weeks	Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in "resistant" muscle or augments it in the "healthy" muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS)