The Effect of High Dose Versus Low Dose Intravenous Vitamin C (Ascorbic Acid)on Burn Injury Resuscitation
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 2
- 主要终点
- Document a significantly lower intravenous fluid requirement per percent total body surface area burn in the High Dose Vitamin C group
研究概览
简要总结
The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.
详细描述
Adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. The danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. Hig dose vitamin C infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. High dose vitamin C is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 72 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>/= 20% total body surface area full and partial thickness burns
- •Admitted to the USAISR burn center within 10 hours post injury
排除标准
- •Pregnant or breast feeding
- •Documented preadmission or admission renal failure
- •History of glucose-6-phosphate dehydrogenase deficiency, kidney stoves, gout or sickle cell
- •Electrical injury
- •Renal replacement of any kind<24 hours after admission
结局指标
主要结局
Document a significantly lower intravenous fluid requirement per percent total body surface area burn in the High Dose Vitamin C group
时间窗: 72 hours
Document a significantly higher number of mechanical ventilator free days
时间窗: 7 days
Document a significantly lower complication and infection rate in the Vitamin C group
时间窗: 7 days
Document decreased lipid peroxidation by monitoring serum malondialdehyde (MDA) level
时间窗: 72 hours
次要结局
- Document a lower incidence of organ failure(30 days)