se of Inhaled vs intravenous sedation & its effect on incidence of delirium

Not Applicable

• Conditions: Health Condition 1: O- Medical and SurgicalHealth Condition 2: 8- Other Procedures

• Registration Number: CTRI/2022/09/045363
• Lead Sponsor: Tata Memorial Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Age 18-80 years

2.BMI 25 to 35 Kg/m2

3.Anticipated Mechanical ventilation for > 24 hrs.

4.Patients who are mechanically ventilated within 48hrs of ICU admission

5.Hemodynamically stable patients (i.e., MAP >65mmHg) with or without vasoactive agents.

6.RASS score -1 to +4 on opioid infusion

7.Patients / surrogate decision maker, willing to enroll in the trial by giving written informed consent. We shall ask for provision of deferred informed consent from the respective IECs.

Exclusion Criteria

1.Patients who as per clinicianââ?¬•s judgement, need deep sedation (RASS -4 or deeper) such as those with severe head injury (GCS < 9) with raised intracranial pressure, severe ARDS (P/F < 100), etc.

2.Malnourished or morbidly obese patients (35 > BMI < 24.9 Kg/m2)

3.Need for neuromuscular blocking agents either as repeated boluses or infusion

4.Contraindications to use of HME filter during mechanical ventilation, these may include, but not limited to: excessive secretions or pulmonary hemorrhage likely to block the filter, indications for reducing apparatus dead space, such as respiratory acidosis

5.Ventilation with Tidal volume below 200 ml

6.Pregnant or breast-feeding women.

7.Family or personal history of malignant hyperthermia.

8.Patients already receiving sedation for more than > 48 hours.

9.Refusal of consent or withdrawal of consent for use of data.

10.Need for elective postoperative ventilation for < 24 hours.

11.Patients with substance abuse, deliberate self harm or any condition that warrants administration of any of the study drugs or any drug that belong to the study drug classification.

Study & Design

• Study Type: Interventional
• Study Design: Not specified