Power Spectral Analysis of the Electroencephalogram During Equi-MAC Sevoflurane vs. Desflurane Anesthesia: A Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Spectral edge frequency 95% value
研究概览
简要总结
The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.
详细描述
Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there were no studies that demonstrate the difference of hypnotic potency using power spectral analysis of electroencephalographic signals (e.g., spectral edge frequency 95%, total power, % value of each bandage). The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics
- •patients with american society of anesthesiologist physical status I, II
- •patients aged 19-65 years
- •patients obtaining written informed consent
排除标准
- •patients with a history of any psychiatric or neurological disease
- •patients who had received any medication affecting the central nervous system
- •patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- •patients undergoing tracheal intubation for airway management
- •pregnant women
研究组 & 干预措施
Sevoflurane
Anesthesia was maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia was maintained with desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
Spectral edge frequency 95% value
时间窗: During about 30 min study period
EEG variables were measured after meeting steady-state anesthesia of 1 MAC.
次要结局
- Bispectral index(During about 30 min study period)
研究者
Kyoung-Ho Ryu, MD
Clinical assistant professor
Kangbuk Samsung Hospital