The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- qCON index
研究概览
简要总结
The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.
详细描述
Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing general anesthesia using volatile anesthetics and intubation
- •patients with american society of anesthesiologist physical status I, II
- •patients obtaining written informed consent
排除标准
- •patients with a history of any psychiatric or neurological disease
- •patients who had received any medication affecting the central nervous system
- •patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- •patients undergoing supraglottic airway for airway management
- •pregnant women
研究组 & 干预措施
Sevoflurane
Anesthesia was maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Isoflurane
Anesthesia was maintained with isoflurane.
干预措施: Isoflurane (Drug)
结局指标
主要结局
qCON index
时间窗: the 10 min at steady-state anesthesia after endotracheal intubation
The hypnotic potency of volatile anesthetics was evaluated by qCON index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).
次要结局
- qNOX index(the 10 min at steady-state anesthesia after endotracheal intubation)