The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Phase 3

Completed

• Conditions: Anesthesia, General
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT02698514
• Lead Sponsor: Kangbuk Samsung Hospital

Brief Summary

The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.

Detailed Description

Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.

Study Timeline

• Study Start: 2016-02-16
• Study First Submitted: 2016-02-22
• Study First Submitted QC: 2016-03-02
• Study First Posted: 2016-03-03
• Primary Completion: 2016-07-13
• Study Completion: 2016-07-13
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-07
• Last Update Posted: 2018-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• patients undergoing general anesthesia using volatile anesthetics and supraglottic airway (I-gel™)
• patients with american society of anesthesiologist physical status I, II
• patients aged 19-65 years
• patients obtaining written informed consent

Exclusion Criteria

• patients with a history of any psychiatric or neurological disease
• patients who had received any medication affecting the central nervous system
• patients who had received medication affecting the sympathetic or parasympathetic nervous systems
• patients undergoing tracheal intubation for airway management
• pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Anesthesia was maintained with sevoflurane.
Desflurane	Desflurane	Anesthesia was maintained with desflurane.

Primary Outcome Measures

Name	Time	Method
Surgical pleth index	the 10 min at steady-state anesthesia after endotracheal intubation	The analgesic potency of volatile anesthetics was evaluated by surgical pleth index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).

Secondary Outcome Measures

Name	Time	Method
Bispectral index	the 10 min at steady-state anesthesia after endotracheal intubation	The hypnotic potency of volatile anesthetics was evaluated by bispectral index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).

Trial Locations

Locations (1)

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Korea, Republic of