The Ratio of Hypnotic to Analgesic Potency of Sevoflurane and Desflurane : Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Surgical pleth index
研究概览
简要总结
The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.
详细描述
Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing general anesthesia using volatile anesthetics and supraglottic airway (I-gel™)
- •patients with american society of anesthesiologist physical status I, II
- •patients aged 19-65 years
- •patients obtaining written informed consent
排除标准
- •patients with a history of any psychiatric or neurological disease
- •patients who had received any medication affecting the central nervous system
- •patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- •patients undergoing tracheal intubation for airway management
- •pregnant women
研究组 & 干预措施
Sevoflurane
Anesthesia was maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia was maintained with desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
Surgical pleth index
时间窗: the 10 min at steady-state anesthesia after endotracheal intubation
The analgesic potency of volatile anesthetics was evaluated by surgical pleth index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).
次要结局
- Bispectral index(the 10 min at steady-state anesthesia after endotracheal intubation)
研究者
Kyoungho Ryu
Clinical assistant professor
Kangbuk Samsung Hospital