Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia

Phase 3

Completed

• Conditions: Anesthesia
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT02872389
• Lead Sponsor: Kangbuk Samsung Hospital

Brief Summary

The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Detailed Description

Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there were no studies that demonstrate the difference of hypnotic potency using power spectral analysis of electroencephalographic signals (e.g., spectral edge frequency 95%, total power, % value of each bandage). The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Study Timeline

• Study First Submitted: 2016-08-10
• Study First Submitted QC: 2016-08-15
• Study Start: 2016-08-16
• Study First Posted: 2016-08-19
• Primary Completion: 2016-12-06
• Study Completion: 2016-12-06
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-02
• Last Update Posted: 2020-09-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics
• patients with american society of anesthesiologist physical status I, II
• patients aged 19-65 years
• patients obtaining written informed consent

Exclusion Criteria

• patients with a history of any psychiatric or neurological disease
• patients who had received any medication affecting the central nervous system
• patients who had received medication affecting the sympathetic or parasympathetic nervous systems
• patients undergoing tracheal intubation for airway management
• pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Anesthesia was maintained with sevoflurane.
Desflurane	Desflurane	Anesthesia was maintained with desflurane.

Primary Outcome Measures

Name	Time	Method
Spectral edge frequency 95% value	During about 30 min study period	EEG variables were measured after meeting steady-state anesthesia of 1 MAC.

Secondary Outcome Measures

Name	Time	Method
Bispectral index	During about 30 min study period	Bispectral index measurements were made after meeting steady-state anesthesia of 1 MAC.

Trial Locations

Locations (1)

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Korea, Republic of