A pilot study of procalcitonin-based algorithms to guide antibiotics treatment in secondary peritonitis after surgery

Not Applicable

Completed

• Conditions: Surgery - Other surgery; Does PCT-based algorithms to guide antibiotic therapy reduce the risk of antibiotics exposure in secondary peritonitis who will receive emergency surgery for acute abdomen without compromising clinical outcomes?; Infection - Other infectious diseases

• Registration Number: ACTRN12612000601831
• Lead Sponsor: Chang Gung Memorial Hospital, Keelung

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-06-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients more than 20 years old who will receive emergency abdominal operations with sepsis due to secondary peritonitis are eligible for enrollment.

Exclusion Criteria

Patients who meet one or more of the following criteria will be excluded: (a) patients who are moribund (life expectance not expected to be > 72 hours because of imminent death) (b) patients with liver cirrhosis, Child’s class B and C liver disease (c) patients with profound septic shock under treatment of high dose inotropic agents (d) pre-existing infection underwent antibiotics treatment (e) multiple traumatized patients with unstable hemodynamic status (f) patients or their family will not participate in this study (g) immunocompromised patients such as HIV infection, long term steroids treatment, post-chemotherapy (h) pregnant women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of antibiotics exposure (days) will be assessed from medical records data.[Post-operative period to discharge.<br>Follow-up 3 months after discharge.];Serious adverse events and adverse events will be assessed by clinically.<br><br>Serious adverse events:<br>Death from any causes is considered as a serious adverse event (SAE).<br><br>Adverse events attributions<br>ICU re-admission for any reason, disease-specific complications (i.e., persistence or development of intra-abdominal infections or abscess, and re-operation) and any intra-abdominal infectious complications in need of further antibiotics treatment after termination of antibiotics according to the studied PCT algorithms are defined as the adverse events (AE).[Post-opertative period to discharge.<br>Follow-up 3 months after discharge.]

Secondary Outcome Measures

Name	Time	Method
The mdical records data will be obtained for cost-effectiveness analysis.[Cost of antibiotics and procalcitonin assays during admission will be recorded. Statistical analysis will be conducted at the end of study.]