Glycemic index testing of cereals and pulse based foods

Not yet recruiting

Conditions: Healthy participants with normal body mass index

Registration Number: CTRI/2022/08/044581

Lead Sponsor: Madras Diabetes Research Foundation

Brief Summary: Research studies have shown thatlifestyle; in particular dietary aspects play an important role in preventing /increasing the burden of the chronic diseases. Dietary habits could thereforebe modified to exert a positive impact in the prevention and treatment. It hasbeen suggested that the high glycemic carbohydrate foods -those foodscontaining carbohydrates which elicit rapid blood glucose rise and therebyincrease the insulin demand leading to hyperinsulinemia, insulin resistance andtype 2 diabetes. Hence, there is a need to understand the blood glucose raisingpotential of foods in India to be of an important tool to aid in the preventionand or management of diabetes and its complication. Thus, evolved the conceptof â€˜Glycemic Indexâ€™ (GI) which ranks the foods, based on the speed at which thefood raises the blood glucose in a scale of 0 to 100, 100 indicating highglycemic index corresponds to oral glucoseâ€™s GI. Today, India leading the worldwith the largest number of adults with diabetes causing a heavy economic burdento the country urgently needs to look at cost effective strategies to combatthis situation. A cost-effective dietary approach like estimating andunderstanding the role of glycemic index of various Indian foods in thelifestyle related diseases like diabetes is urgently needed.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 15

Inclusion Criteria

Age 18 to 45 years BMI greater than 18.5 to less than 22.9 kg/ m2 (as per WHO cut off for normal BMI) Both male and female Willingness to consume the test foods no known food allergy or intolerance; no medications known to affect glucose tolerance (excluding oral contraceptives) â€” stable doses of oral contraceptives, acetylsalicylic acid, thyroxin, vitamins and mineral supplements or drugs to treat hypertension or osteoporosis are acceptable.

Exclusion Criteria

a known history of diabetes mellitus or the use of anti-hyperglycemic drugs or insulin to treat diabetes and related conditions pregnant or lactating women a major medical or surgical event requiring hospitalization within the preceding 3 months; the presence of disease or drug(s) which influence digestion and absorption of nutrients; the use of steroids, protease inhibitors or antipsychotics (all of which have major effects on glucose metabolism and body fat distribution).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glycemic index and category of test foods- low glycemic micronutrient enriched kavuni rice analogue, high fibre ready to use multigrain roti mix, barnyard millet puttu mix, Multigrain adai mix, millet and pulse blended functional pasta .	Each food will be given to the participants on separate occasions in fasting state and capillary blood samples will be collected at fasting (0 min), and post consumption of test and reference food at 15,30,45,60,90 and 120 mins

Secondary Outcome Measures

Name	Time	Method
NA	NA

Trial Locations

Locations (1): Madras Diabetes Research Foundation
🇮🇳
Chennai, TAMIL NADU, India
Madras Diabetes Research Foundation
🇮🇳Chennai, TAMIL NADU, India
Sudha Vasudevan
Principal investigator
044439688888
s2r_7@mdrf.in