The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

Not Applicable

Completed

• Conditions: Exercise; Ketones; Dietary Supplements
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Ketone Salt

• Registration Number: NCT02825823
• Lead Sponsor: University of British Columbia

Brief Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07
• Study First Submitted: 2016-07-04
• Study First Submitted QC: 2016-07-04
• Study First Posted: 2016-07-07
• Primary Completion: 2017-06-01
• Study Completion: 2017-06-01
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-12
• Last Update Posted: 2017-10-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Males aged 18-40
• Ability to understand and communicate in English to answer questionnaires and interact with the research assistant
• Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

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Exclusion Criteria

• Diagnosed with diabetes or any other medical conditions that could affect metabolism.
• Diagnosed with heart disease or taking anti-hypertensive medications.
• Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
• Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
• Current consumption of ketone supplements
• Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Acute dose of taste-matched placebo (0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)
Ketone Salts	Ketone Salt	Acute dose of beta-hydroxybutyrate potassium/sodium salt (0.2g beta-hydroxybutyrate/kg, 0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)

Primary Outcome Measures

Name	Time	Method
Respiratory Exchange Ratio (RER) during cycling exercise	0-18 minutes	The RER during 18 minutes of steady-state exercise

Secondary Outcome Measures

Name	Time	Method
10 km Cycling Time Trial Performance	Following 18 minutes of steady-state exercise	10 km time trial performed on a stationary bicycle following 18 minutes of steady-state exercise

Trial Locations

Locations (1)

University of British Columbia, Okanagan.; 🇨🇦 Kelowna, British Columbia, Canada