Does giving kidney donors intravenous fluids the night before kidney donation make any difference?
Completed
- Conditions
- ive kidney donorsUrological and Genital Diseases
- Registration Number
- ISRCTN10199225
- Lead Sponsor
- HS Greater Glasgow and Clyde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 86
Inclusion Criteria
1. Adult patients aged >18 years of age undergoing live donor hand-assisted laparoscopic nephrectomy eligible to participate
2. Consent to participate given
3. English-speaking or appropriate translation facilities to allow for consent to be valid
4. Living donor transplant in Western Infirmary, Glasgow
5. Transplant taking place between dates of the trial
Exclusion Criteria
1. Patients undergoing open nephrectomy
2. Patients unable/unwilling to consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Day +1 acute kidney injury (as measured by N-GAL)
- Secondary Outcome Measures
Name Time Method 1. Day 1 change in donor N-GAL from baseline<br>2. Donor renal function (serum creatinine and eGFR) day 1-4, week 6 and 1 year, as is standard procedure<br>3. Donor BNP (Day -1, Day 0, Day 1)<br>4. Recipient change in N-GAL from baseline<br>5. Recipient serum creatinine and eGFR at 6 weeks and 1 year<br>6. Delayed graft function (DGF) – defined as use of dialysis in the first week postoperatively <br>7. 1-year graft and patient survival in recipient<br>8. Intraoperative haemodynamics (including blood pressure, heart rate, stroke volume, cardiac index and systemic vascular resistance index) and response to fluid challenge<br>9. N-GAL levels in blood obtained from renal vein during retrieval and implantation surgery<br>10. Perioperative mortality<br>11. Perioperative fluid balance<br>12. Perioperative complications (including cardiorespiratory complications, time to first bowel motion, infective complications, length of hospital stay, readmission)<br>13. Donor sleep quality