Comparison of the effects of oral and intravenous acetylcysteine ??in treating acetaminophen poisoning
Phase 3
- Conditions
- Acetaminophen Poisoning.Other nonopioid analgesics and antipyretics, not elsewhere classified
- Registration Number
- IRCT201112218488N1
- Lead Sponsor
- Research Deputy of School of Medicine, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
Patients over 18 years old age which admitted to toxicological emergency ward of Baharloo hospital in Tehran which consume 7.5 gr acetaminophen during 24 hr ago will be conclude in the study.
Inclusion Criteria: Patients over 18 years old age; consumption 7.5 gr acetaminophen during 24 hr before admittion
Exclusion Criteria
Admission after 24 hr after consumption of acetaminophen; Co ingestion of cholinergic drugs; Primary unconsciousness; Primary hepatic encephalopathy; Presence of status epilepticus after NAC therapy; History of asthma and anaphylactiod reactions
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AST. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration.;ALT. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration.;Bilirubin. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration.;Prothrombin time. Timepoint: First of the study and 72 hour after treatment. Method of measurement: Serum concentration.
- Secondary Outcome Measures
Name Time Method Treatment complication. Timepoint: At the first of the study up to 24 hour. Method of measurement: upon history and physical examination during treatment.