The effect of Colchicine on the release of Neutrophil Extra-cellular Traps after Percutaneous Coronary Intervention in Acute Coronary Syndrome Patients..

Phase 4

Completed

• Conditions: Acute coronary syndrome; Stable Angina Pectoris; Cardiovascular - Coronary heart disease; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12619001231134
• Lead Sponsor: Sanjay Patel

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-04-07
• Study Start: 2019-09-06
• Last Update Posted: 30 September 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with clinical indication for coronary angiogram and percutaneous coronary intervention.

Exclusion Criteria

- Patients with >50% Left main artery stenosis
- Patients with cardiogenic shock
- Patients with haemodynamic instability
- Patients currently lactating
- Patients with known colchicine hypersensitivity
- Patients already taking colchicine before the procedure.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary Sinus Neutrophil Extracellular Traps (NETs) Area Under the Curve (AUC) measured using serum assays.[Calculated from five 45-second intervals peri-procedure.];Coronary Sinus Human Neutrophil Elastase (HNE) AUC measured using serum assays.[Calculated from five 45-second intervals peri-procedure.];Coronary Sinus Myeloperoxidase (MPO) AUC measured using serum assays.[Calculated from five 45-second intervals peri-procedure.]

Secondary Outcome Measures

Name	Time	Method
Change in peripheral NETs level measured using serum assays.[Within 24 hours (difference pre-and post procedure).<br><br>Pre-procedure is immediately before stent deployment<br>Post-procedure is 3 minutes post stent deployment];Change in peripheral HNE level measured using serum assays.[Within 24 hours (difference pre-and post procedure).<br><br>Pre-procedure is immediately before stent deployment<br>Post-procedure is 3 minutes post stent deployment];Change in peripheral MPO level measured using serum assays.[Within 24 hours (difference pre-and post procedure).<br><br>Pre-procedure is immediately before stent deployment<br>Post-procedure is 3 minutes post stent deployment];Change in peripheral high-sensitivity Troponin-T level measured using serum assays.[Within 24 hours (difference pre-and post procedure).<br><br>Pre-procedure is immediately before stent deployment<br>Post-procedure is 3 minutes post stent deployment]