The effect of colchicine on neutrophils in patients presenting with an acute coronary syndrome (ACS)
Phase 2
- Conditions
- Coronary artery diseaseAcute coronary syndromeCardiovascular - Coronary heart disease
- Registration Number
- ACTRN12619001005145
- Lead Sponsor
- A/Prof Sanjay Patel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age >= 18 years
ACS patients < 48 hours post presentation
Exclusion Criteria
Colchicine treatment for another cause
Severe liver disease
Renal insufficiency with creatinine clearance < 45 ml/min
Calcineurin inhibitor treatment
Hypersensitivity to colchicine
Haematological malignancy or antineoplastic therapy
Thrombocytopenia or leukopenia
Pregnancy, lactating women or women at risk of pregnancy
Strong CYP3A4 inhibitors
Chronic inflammatory bowel disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in reactivity of isolated neutrophils as measured by Sytox green NETosis assay previously described by Khan & Palaniyar (2017). [Baseline and 24-hours post intervention ]
- Secondary Outcome Measures
Name Time Method Change in myeloperoxidase concentration in isolated neutrophils. This will be analysed using enzyme-linked immunosorbent assay. [Baseline and 24-hours post intervention];Presence or absence of low-density neutrophils, as previously described by Sagiv, Voels & Granot (2016). [Baseline and 24-hours post intervention];Difference in neutrophil activation between patients with stable coronary artery disease and those presenting with an acute coronary syndrome, as measured by by Sytox green NETosis assay previously described by Khan & Palaniyar (2017). [Baseline and 24-hours post intervention]