A comparison of clinical outcomes between cefazolin and nafcillin therapy for methicillin-susceptible Staphylococcus aureus bacteremia
Not Applicable
Completed
- Conditions
- Certain infectious and parasitic diseases
- Registration Number
- KCT0001081
- Lead Sponsor
- Seoul National University Bundang Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
Among all adult (>=18years) patient with MSSA bacteremia at participating hospitals was ascertained during the study period
1) Patient who received cefazolin or nafcillin as definite antibiotics
2) Patient who agree the gathering clinical information about S. aureus bacteremia by inform consent.
3) Patient who fulfill the criteria of waiver of informed consent: Patient who died or transferred within 2 weeks after the onset of bacteremia was waived by institutional review board.
Exclusion Criteria
Patient who do not agree the participation in this study, except for patient who fulfill the criteria of waiver of informed consent.
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Treatment failure: [(1) switching antibiotics due to clinical failure; (2) premature discontinuation of antibiotics due to drug adverse effect, (3) recurrence of MSSA bacteremia, or (4) MSSA bacteremia associated mortality];3 months mortality
- Secondary Outcome Measures
Name Time Method Persistent bacteremia;7day mortality;Analysis of clinical implication of cefazolin inoculum effect