Evaluation of Cardiopulmonary Parameters in Individuals With Asthma

Recruiting

• Conditions: Asthma
• Interventions: Other: Exercise capacity

• Registration Number: NCT06449573
• Lead Sponsor: Hacettepe University

Brief Summary

The aim of the study compare the cardiopulmonary parameters of individuals with asthma with healthy subjects.

Detailed Description

It is thought that aerobic capacity of asthmatic individuals decreases due to chronic respiratory disease, especially oxygen consumption. Detailed investigation will be provided with this research.

Study Timeline

• Study Start: 2024-03-01
• Study First Submitted: 2024-03-03
• Study First Submitted QC: 2024-06-07
• Study First Posted: 2024-06-10
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-26
• Last Update Posted: 2024-08-27
• Primary Completion: 2025-03
• Study Completion: 2025-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• No respiratory, cardiovascular and metabolic diseases
• Regular non-smoker

Exclusion Criteria

• Non-consenting
• Pregnant women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Asthma	Exercise capacity	Inclusion Criteria: * Patients receiving step 5 asthma treatment * 18-65 years * Asthma under control (asthma control test ≥20) * No more than 2 exacerbations in the last 1 year Exclusion Criteria: * Non-consenting * Patients with asthma exacerbation requiring systemic steroid use for at least 3 days in the last 1 month * Being an active smoker
Healthy Individuals	Exercise capacity	Inclusion Criteria: * No respiratory, cardiovascular and metabolic diseases * Regular non-smoker Exclusion Criteria: * Non-consenting * Pregnant women

Primary Outcome Measures

Name	Time	Method
Exercise capacity	20 minutes	Exercise capacity will be assessed by Cardiopulmonary Exercise Test. The test will be performed on a bicycle ergometer. The test will be terminated when the target heart rate is reached or when the patient indicates that they are unable to continue the test. maximal oxygen consumption and the workload achieved will be recorded.

Secondary Outcome Measures

Name	Time	Method
Respiratory muscle strength	8 minutes	Inspiratory and expiratory muscle strength will be measured with a mouth pressure measuring device. Measurements will be made in a sitting position with the hip and knee at 90 degrees and the trunk upright.
Peripheral muscle strength	5 minutes	It will be evaluated with a portable manual muscle strength measuring device. Muscle strength of knee extensors will be measured. The measurement will be performed with the patient sitting with his/her back unsupported and his/her hands crossed on his/her chest.
Grip strength	3 minutes	It will be evaluated with a portable hand dynamometer. Measurements will be made in a sitting position with the hip and knee at 90 degrees and the trunk upright. The measurement will be performed with the arm adjacent to the side of the trunk and the forearm parallel to the ground.
Quality of Life (symptoms, mood, activity limitation, environmental exposure)	10 minutes	Asthma Quality of Life Scale will be used for the evaluation. This scale consists of 4 sub-headings including symptoms, mood, activity limitation, environmental exposure and 32 questions. Each item is scored between 1-7. The total score of the scale is calculated by averaging the scores given to the items. The higher the score, the better the quality of life.
Kinesiophobia	3 minutes	Tampa Kinesiophobia Scale will be used. A total of 17 questions will be answered in 4-point Likert form. In total, the patient scores between 17-68. A high score indicates high kinesiophobia.

Trial Locations

Locations (1)

Hacettepe University; 🇹🇷 Ankara, Turkey