The Role of Alternatively Activated Brown Fat in Bariatric Surgery-mediated Metabolic Improvements
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Changes in BAT activity after bariatric surgery
研究概览
简要总结
The mechanisms of bariatric surgery-induced weight loss go beyond reductions in calorie intake and may involve several other pathways. Recently, brown adipose tissue (BAT) has been added as another potential player. Activation of BAT results in enhanced energy expenditure and promotes weight loss. Here, the investigators will study the effects of bariatric surgery on BAT function by PET/CT studies and molecular analyses of adipose biopsies. The investigators will explore different pathways that may affect BAT activation in this patient population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 20 - 50 years
- •Body mass index (BMI) 35 - 55kg/m2
排除标准
- •Endocrine disease (except hyperlipidemia and substituted hypothyroidism or type 2 diabetes with fasting glucose concentrations <120mg/dl), kidney disease, inflammatory bowel disease, autoimmune or rheumatologic diseases that require immunosuppressive treatment, active oncologic disease, heart failure.
- •Medication for any of the above mentioned conditions.
- •Antibiotic treatment in the past three months
- •Pregnancy
结局指标
主要结局
Changes in BAT activity after bariatric surgery
时间窗: 4 years
The primary outcome of this study is to determine whether Omega Loop Gastric Bypass and Sleeve Gastrectomy result in increased BAT activity
次要结局
- Bariatric surgery-induced changes in gut microbiota, bile acid composition and other circulating factors(4 years)
- Association between changes in BAT activity, transcriptional BAT markers and alterations in the gut microbiota profile or bile acid composition(4 years)
研究者
Dr. Florian Kiefer
Associate Professor of Medicine
Medical University of Vienna