Impact of Yoga and Meditation on mitochondrial health, Telomere length and differentially expressed miRNA in POAG
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Decrease in IOP
研究概览
简要总结
We have planned this study to see the effect of yoga as a lifestyle intervention in POAG patients. Patients will undergo a structured and pre-tested yoga program. The supervised yoga-based intervention (including gentle physical movements and postures (asanas), breathing techniques (pranayamas), meditation, and lectures on yoga philosophy) is a regular outpatient-based program, practiced for two hours each day for the 21 days. Following the yoga intervention the patients will become less anxious with better coping mechanism. This study will also enlighten the effect of yoga on biomarkers of inflammation and oxidative stress in POAG and to further understand the pathogenesis of the disease. Thus, it may be possible to use it as an adjunct therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 40.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with moderate to advanced primary open angle glaucoma who are planned for trabeculectomy.
- •Age more than 40 years Uncontrolled IOP on maximum topical medications Willful to attend full course of intervention.
- •Conversant in Hindi and/or English.
排除标准
- •Refusal to participate in study.
- •Patients with other types of glaucoma.
- •Systemic co-morbidities (Depression, diabetes, coronary artery disease, cerebrovascular disease etc.).
- •Any co morbid ocular condition (corneal opacity, retinal pathologies, optic neuropathy other than glaucoma).
- •History of ocular surgery within past 6 months Patients on medical therapy for other diseases Subnormal mentation and patients with communication difficulties Already practicing Yoga and meditation in any form.
- •Age less than 40 years.
结局指标
主要结局
Decrease in IOP
时间窗: Baseline, Day=21 or 3 weeks
次要结局
- Decrease in Oxidative stress(Increase in Telomere length)
研究者
Dr MANOJ KUMAR
AIIMS, New Delhi