The relation between cerebral blood flow, pain attenuation and autonomic parameters in rest, during and after exercise in patients with the chronic fatigue syndrome.

Completed

Conditions: chronisch vermoeidheidssyndroom
chronic fatigue syndrome
myalgic encephalitis

Registration Number: NL-OMON40186

Lead Sponsor: ZBC Stichting Cardiozorg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 650

Inclusion Criteria

CFS patients within the range of 18-65 years of age, who are diagnosed according to the Centre of Disease Control criteria
Before being asked to participate to the study, the International Physical Questionnaire *short form, Dutch version- will be sent to potential candidates. Only those with categorical score: *low* will be asked to participate.

Exclusion Criteria

- Pregnancy or being postnatal within 1 year.
- - The current use of opioid medication.
- BMI >30.
- Unable to perform a maximal exercise test.
- Diabetes mellitus.
- Medical condition leading to chronic pain in sedentary controls.
- Suspicion of ischaemic complaints, regional wall motion abnormality or moderate to severe valvular disease.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome of this study is the relationship between decreased<br /><br>cerebral blood flow during exercise and increased pain sensation after<br /><br>exercise.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary Outcomes:<br /><br>- Cerebral blood flow before and after tilt table testing<br /><br>- Comparison of CBF changes between exercise and tilt table testing<br /><br>- Comparison of CBF changes between patients and healthy subjects<br /><br>- Comparison of PPT between patients and healthy subjects<br /><br>- Comparison of peak oxygen consumption between patients and healthy subjects<br /><br>- Relation of CBF and an increase in oxygen consumption during exercise.<br /><br>- Comparison of Vasalva maneuver measurements between patients and healthy<br /><br>subjects<br /><br>- Comparison of questionnaires between patients and healthy subjects.</p><br>