Effect of different doses of ketamine on prevention of fentanyl induced coughing
- Conditions
- Candidate patients for surgery under general anesthesia using fentanyl.
- Registration Number
- IRCT20200825048515N55
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 56
Age category 65-18 years
Candidate for surgery under general anesthesia using fentanyl
American Society of Anesthesiologists (ASA) I or II
Satisfaction to participate in the study
Underlying diseases (including heart failure, respiratory, liver, kidney, myocardial ischemic disease, myocardial infarction, hypertension above 140/90 mm Hg, tachycardia (heart rate above 100 beats per minute), depression, asthma, chronic cough)
History of allergy to the studied drugs
Smoking, addiction
Having an upper respiratory infection within the last month
Use of drugs such as angiotensin converting enzyme inhibitors (ACEIs), antidepressants (over the past two weeks), and steroids (over the past two weeks) that interfere with the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intensity of cough. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Fentanyl-Induced Cough Scale (FIC).
- Secondary Outcome Measures
Name Time Method Systolic blood pressure. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Hear rate. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.