The effects of radioiodine treatment on the occurrence of tooth cavities in patients with thyroid cancer
- Conditions
- dental cariesradioiodine treatment (I131)differentiated thyroid carcinoma (DTC)salivary glands
- Registration Number
- NL-OMON29082
- Lead Sponsor
- T.P. Links, University Medical Center Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
age at time of the first I131 treatment is at least 26 years
- the patient is diagnosed with DTC at least 4 years ago
Exclusion Criteria
- history of Sjögren’s syndrome or other salivary gland disease affecting salivary gland function
- the patient switched dentist in the period of 4 years before and 4 years after the first radioiodine therapy, with no (complete) transfer of the dental record.
Study & Design
- Study Type
- Not specified
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incident dental caries lesions, extracted from the dental record (includes number of caries restorations, tooth extractions and documented carious lesions)
- Secondary Outcome Measures
Name Time Method - Cumulative I131 dose <br /><br>- Number of I131 therapies<br /><br>- Xerostomia and oral hygiene questionnaire scores<br /><br>- Unstimulated and chewing stimulated whole saliva flow rates and pH<br /><br>- Site of carious lesions<br /><br>- Dutch Periodontal Screening Index (DPSI) score.