Erlotinib Hydrochloride or Crizotinib and Chemoradiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer

Phase 2

Terminated

Conditions: Stage IIIA Non-Small Cell Lung Cancer AJCC v7
Stage III Non-Small Cell Lung Cancer AJCC v7
Stage IIIB Non-Small Cell Lung Cancer AJCC v7

Interventions: Radiation: Radiation Therapy
Drug: Carboplatin
Drug: Cisplatin
Drug: Erlotinib
Drug: Crizotinib
Drug: Etoposide
Drug: Paclitaxel

Registration Number: NCT01822496

Lead Sponsor: National Cancer Institute (NCI)

Brief Summary: This randomized phase II trial studies how well erlotinib hydrochloride or crizotinib with chemoradiation therapy works in treating patients with stage III non-small cell lung cancer. Radiation therapy uses high energy x rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin, etoposide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving erlotinib hydrochloride is more effective than crizotinib with chemoradiation therapy in treating patients with non-small cell lung cancer.

Detailed Description: PRIMARY OBJECTIVES:

I. To assess whether patients with unresectable local-regionally advanced non-small cell lung cancer (NSCLC) treated with targeted agents based on molecular characteristics have a longer progression-free survival than those treated with standard care therapy alone.

SECONDARY OBJECTIVES:

I. To evaluate response rate. II. To assess toxicity. III. To assess overall survival. IV. To correlate clinical outcomes with tumor molecular aberrations identified from deep sequencing of selected kinomes in patients from whom adequate baseline tissue is available.

OUTLINE: Eligible patients are assigned to one of two cohorts based on pre-enrollment screening by the enrolling institution for two biomarkers: EGFR TK mutation and EML4-ALK fusion arrangement. Within each cohort, patients are randomized to either an experimental or control arm, resulting in a total of four treatment arms overall. Patients with both the EGFR mutation and ALK arrangement are placed in the ALK Cohort.

Planned Sample Size: 156 for the EGFR mutation cohort and 78 for the ALK translocation cohort

After completion of study treatment, patients are followed at 1 and 2 months, 4-6 weeks, every 3 months for 2 years, every 6 months for 3 years, and then annually for 5 years.

Recruitment & Eligibility

Status: TERMINATED

Sex: All

Target Recruitment: 59

Inclusion Criteria

Histologically or cytologically confirmed, newly diagnosed non-squamous NSCLC
Unresectable stage IIIA or IIIB disease; patients must be surgically staged to confirm N2 or N3 disease; patients may have invasive mediastinal staging by mediastinoscopy, mediastinotomy, endobronchial ultrasound transbronchial aspiration (EBUS-TBNA), endoscopic ultrasound (EUS), or video-assisted thoracoscopic surgery (VATS)
Patients with any tumor (T) with node (N)2 or N3 are eligible; patients with T3, N1-N3 disease are eligible if deemed unresectable; patients with T4, any N are eligible
Patients must have measurable disease, i.e., lesions that can be accurately measured in at least 1 dimension (longest dimension in the plane of measurement is to be recorded) with a minimum size of 10 mm by computed tomography (CT) scan (CT scan slice thickness no greater than 5 mm)
Patients with a pleural effusion, which is a transudate, cytologically negative and non-bloody, are eligible if the radiation oncologist feels the tumor can be encompassed within a reasonable field of radiotherapy
If a pleural effusion can be seen on the chest CT but not on chest x-ray and is too small to tap, the patient will be eligible; patients who develop a new pleural effusion after thoracotomy or other invasive thoracic procedure will be eligible
The institution's pre-enrollment biomarker screening at a Clinical Laboratory Improvement Amendments (CLIA) certified lab documents presence of known "sensitive" mutations in epidermal growth factor receptor tyrosine kinase (EGFR TK) domain (exon 19 deletion, L858) and/or EML4-anaplastic lymphoma kinase (ALK) fusion arrangement; either the primary tumor or the metastatic lymph node tissue may be used for testing of mutations
The institution's pre-enrollment biomarker screening at a CLIA certified lab documents absence of T790M mutation in the EGFR TK domain
Appropriate stage for protocol entry, including no distant metastases, based upon the following minimum diagnostic workup:
- History/physical examination, including recording of pulse, blood pressure (BP), weight, and body surface area, within 45 days prior to registration
- Whole body fludeoxyglucose-positron emission tomography (FDG-PET)/CT (orbits to mid-thighs) within 30 days prior to registration; PET/CT must be negative for distant metastasis
- CT scan with contrast of the chest and upper abdomen to include liver and adrenals (unless medically contraindicated) within 30 days prior to registration
- Magnetic resonance imaging (MRI) of the brain with contrast (or CT scan with contrast, if MRI medically contraindicated) within 30 days prior to registration
Zubrod performance status 0-1 within 14 days prior to registration
Absolute neutrophil count (ANC) >= 1,000 cells/mm^3
Platelets >= 100,000 cells/mm^3
Hemoglobin >= 8.0 g/dl (Note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8.0 g/dl is acceptable)
Serum creatinine < 1.5 mg/dL or calculated creatinine clearance >= 50 ml/min (by Cockcroft-Gault formula) within 14 days prior to registration
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) within 14 days prior to registration
Bilirubin within normal institutional limits within 14 days prior to registration
Negative serum pregnancy test within 14 days prior to registration for women of childbearing potential
Patient must provide study specific informed consent prior to study entry, including consent for mandatory screening of tissue

Exclusion Criteria

Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 730 days (2 years) (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible)
Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
Atelectasis of the entire lung
Contralateral hilar node involvement
Exudative, bloody, or cytologically malignant effusions
Severe, active co-morbidity, defined as follows:
- Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
- Transmural myocardial infarction within the last 6 months
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
- Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration; hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
- Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients
Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
Prior allergic reaction to the study drug(s) involved in this protocol

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
EGFR: Erlotinib	Radiation Therapy	Induction erlotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
ALK: No Crizotinib	Radiation Therapy	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
EGFR: No Erlotinib	Radiation Therapy	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
ALK: Crizotinib	Radiation Therapy	Induction crizotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: Erlotinib	Carboplatin	Induction erlotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: Erlotinib	Cisplatin	Induction erlotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: Erlotinib	Etoposide	Induction erlotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: Erlotinib	Erlotinib	Induction erlotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: Erlotinib	Paclitaxel	Induction erlotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: No Erlotinib	Cisplatin	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
EGFR: No Erlotinib	Carboplatin	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
EGFR: No Erlotinib	Etoposide	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
ALK: Crizotinib	Carboplatin	Induction crizotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
ALK: Crizotinib	Cisplatin	Induction crizotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
EGFR: No Erlotinib	Paclitaxel	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
ALK: Crizotinib	Crizotinib	Induction crizotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
ALK: Crizotinib	Etoposide	Induction crizotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
ALK: Crizotinib	Paclitaxel	Induction crizotinib for 12 weeks followed by chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy. Patients who have had no response (partial or complete) after 6 weeks of induction therapy start chemoradiation therapy immediately.
ALK: No Crizotinib	Carboplatin	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
ALK: No Crizotinib	Cisplatin	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
ALK: No Crizotinib	Etoposide	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.
ALK: No Crizotinib	Paclitaxel	Chemotherapy (either cisplatin/etoposide or paclitaxel/carboplatin) and radiation therapy.

Primary Outcome Measures

Name	Time	Method
Progression-free Survival	From randomization to study termination. Maximum follow-up was 39.0 months	Progression is defined using the Response Evaluation Criteria In Solid Tumors Criteria (RECIST) guideline v1.1 as a 20% increase in the sum of the longest diameter of target lesions, a measurable increase in a non-target lesion, or the appearance of new lesions at any location. Progression-free survival time is measured from the date of randomization to the date of first progression, death, or last known follow-up (censored). No statistical testing was done due to early study termination.

Secondary Outcome Measures

Name	Time	Method
Percentage of Patients With Complete or Partial Response	From randomization to study termination. Maximum follow-up was 39.0 months	Per the RECIST guideline v1.1 complete response is defined as the disappearance of all target lesions; any pathological lymph nodes (whether target or non-target) must have reduction in short axis to \<10 mm. Partial response is defined as at least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters. No statistical testing was done due to early study termination.
Number of Patients With Grade 3-5 Adverse Events	From randomization to study termination. Maximum follow-up was 39.0 months	Adverse events (AE) are graded using the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Grade refers to the severity of the AE. The CTCAE v4.0 assigns Grades 1 through 5 with unique clinical descriptions of severity for each AE based on this general guideline: Grade 1 Mild AE, Grade 2 Moderate AE, Grade 3 Severe AE, Grade 4 Life-threatening or disabling AE, Grade 5 Death related to AE.
Correlation Between Clinical Outcomes and Tumor Molecular Aberrations	Baseline
Overall Survival	From randomization to study termination. Maximum follow-up was 39.0 months	Overall survival time is defined as time from randomization to the date of death from any cause. Overall survival rates are estimated by the Kaplan-Meier method. Patients last known to be alive are censored at the date of last contact.
Distant Progression-free Survival	From randomization to study termination. Maximum follow-up was 39.0 months	Distant progression is defined as the first occurrence of distant metastasis. Distant progression-free survival time is measured from the date of randomization to the date of first distant progression, death, or last known follow-up (censored). Distant progression-free survival rates are estimated using the Kaplan-Meier method. No testing was done due to early study termination.
Local-regional Progression-free Survival	From randomization to study termination. Maximum follow-up was 39.0 months	Progression is defined using the RECIST guideline v1.1 as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new regional lesions. Local progression is defined as progression within the planning target volume (PTV). Regional progression is defined as progression outside of the PTV but within the same lobe of the lung as the primary tumor or in regional lymph nodes as defined by the American Joint Committee on Cancer (AJCC) 7th edition nodal stations. Local-regional progression-free survival time is measured from the date of randomization to the date of first local-regional progression, death, or last known follow-up (censored). Local-regional progression-free survival rates are estimated using the Kaplan-Meier method. No testing was done due to early study termination.

Trial Locations

Locations (173): Lahey Hospital and Medical Center
🇺🇸
Burlington, Massachusetts, United States
University of Illinois
🇺🇸
Chicago, Illinois, United States
Baptist Medical Center South
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Jacksonville, Florida, United States
Robert and Carol Weissman Cancer Center at Martin Health
🇺🇸
Stuart, Florida, United States
Unity Hospital
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Fridley, Minnesota, United States
The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
🇺🇸
Hollywood, Florida, United States
Emory University Hospital Midtown
🇺🇸
Atlanta, Georgia, United States
Saint Mary Mercy Hospital
🇺🇸
Livonia, Michigan, United States
Emory University Hospital/Winship Cancer Institute
🇺🇸
Atlanta, Georgia, United States
21st Century Oncology-Palatka
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Palatka, Florida, United States
Edward Hospital/Cancer Center?Plainfield
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Plainfield, Illinois, United States
Saint Luke's Hospital
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Cedar Rapids, Iowa, United States
Memorial Hospital West
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Pembroke Pines, Florida, United States
Integrated Community Oncology Network-Flager Cancer Center
🇺🇸
Saint Augustine, Florida, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Deerfield Beach, Florida, United States
Baptist MD Anderson Cancer Center
🇺🇸
Jacksonville, Florida, United States
McFarland Clinic PC - Ames
🇺🇸
Ames, Iowa, United States
Emory Saint Joseph's Hospital
🇺🇸
Atlanta, Georgia, United States
Crossroads Cancer Center
🇺🇸
Effingham, Illinois, United States
AMITA Health Alexian Brothers Medical Center
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Elk Grove Village, Illinois, United States
AMITA Health Cancer Institute and Outpatient Center
🇺🇸
Hinsdale, Illinois, United States
Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States
Staten Island University Hospital
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Staten Island, New York, United States
University of New Mexico Cancer Center
🇺🇸
Albuquerque, New Mexico, United States
Decatur Memorial Hospital
🇺🇸
Decatur, Illinois, United States
Elmhurst Memorial Hospital
🇺🇸
Elmhurst, Illinois, United States
SwedishAmerican Regional Cancer Center/ACT
🇺🇸
Rockford, Illinois, United States
Saint Vincent Anderson Regional Hospital/Cancer Center
🇺🇸
Anderson, Indiana, United States
Case Western Reserve University
🇺🇸
Cleveland, Ohio, United States
Mount Sinai Union Square
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New York, New York, United States
Park Nicollet Clinic - Saint Louis Park
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Saint Louis Park, Minnesota, United States
Miller-Dwan Hospital
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Duluth, Minnesota, United States
Adena Regional Medical Center
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Chillicothe, Ohio, United States
Weill Medical College of Cornell University
🇺🇸
New York, New York, United States
Cancer Care of Western North Carolina
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Asheville, North Carolina, United States
Summa Akron City Hospital/Cooper Cancer Center
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Akron, Ohio, United States
Cleveland Clinic Cancer Center/Fairview Hospital
🇺🇸
Cleveland, Ohio, United States
Delbert Day Cancer Institute at PCRMC
🇺🇸
Rolla, Missouri, United States
Grant Medical Center
🇺🇸
Columbus, Ohio, United States
Southeast Cancer Center
🇺🇸
Cape Girardeau, Missouri, United States
Elliot Hospital
🇺🇸
Manchester, New Hampshire, United States
Mary Imogene Bassett Hospital
🇺🇸
Cooperstown, New York, United States
Geisinger Medical Center
🇺🇸
Danville, Pennsylvania, United States
FirstHealth of the Carolinas-Moore Regional Hospital
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Pinehurst, North Carolina, United States
Mount Sinai Hospital
🇺🇸
New York, New York, United States
Paoli Memorial Hospital
🇺🇸
Paoli, Pennsylvania, United States
Cleveland Clinic Foundation
🇺🇸
Cleveland, Ohio, United States
Guthrie Medical Group PC-Robert Packer Hospital
🇺🇸
Sayre, Pennsylvania, United States
The Mark H Zangmeister Center
🇺🇸
Columbus, Ohio, United States
Cleveland Clinic Akron General
🇺🇸
Akron, Ohio, United States
Mission Hospital-Memorial Campus
🇺🇸
Asheville, North Carolina, United States
Intermountain Medical Center
🇺🇸
Murray, Utah, United States
PeaceHealth Southwest Medical Center
🇺🇸
Vancouver, Washington, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
🇺🇸
Miami, Florida, United States
Hennepin County Medical Center
🇺🇸
Minneapolis, Minnesota, United States
UCSF Medical Center-Mount Zion
🇺🇸
San Francisco, California, United States
Rocky Mountain Cancer Centers-Boulder
🇺🇸
Boulder, Colorado, United States
University of Rochester
🇺🇸
Rochester, New York, United States
UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, United States
Queen's Medical Center
🇺🇸
Honolulu, Hawaii, United States
Penrose-Saint Francis Healthcare
🇺🇸
Colorado Springs, Colorado, United States
McKee Medical Center
🇺🇸
Loveland, Colorado, United States
University of Oklahoma Health Sciences Center
🇺🇸
Oklahoma City, Oklahoma, United States
Providence Portland Medical Center
🇺🇸
Portland, Oregon, United States
University of Colorado Hospital
🇺🇸
Aurora, Colorado, United States
Moffitt Cancer Center
🇺🇸
Tampa, Florida, United States
Mayo Clinic
🇺🇸
Rochester, Minnesota, United States
Nebraska Methodist Hospital
🇺🇸
Omaha, Nebraska, United States
AIS Cancer Center at San Joaquin Community Hospital
🇺🇸
Bakersfield, California, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center
🇺🇸
Truckee, California, United States
Northwestern University
🇺🇸
Chicago, Illinois, United States
Loyola University Medical Center
🇺🇸
Maywood, Illinois, United States
Ohio State University Comprehensive Cancer Center
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Columbus, Ohio, United States
Lankenau Medical Center
🇺🇸
Wynnewood, Pennsylvania, United States
Cleveland Clinic Cancer Center Independence
🇺🇸
Independence, Ohio, United States
University of Alabama at Birmingham Cancer Center
🇺🇸
Birmingham, Alabama, United States
Mayo Clinic in Arizona
🇺🇸
Scottsdale, Arizona, United States
Providence Alaska Medical Center
🇺🇸
Anchorage, Alaska, United States
UC San Diego Moores Cancer Center
🇺🇸
La Jolla, California, United States
Fremont - Rideout Cancer Center
🇺🇸
Marysville, California, United States
Mercy UC Davis Cancer Center
🇺🇸
Merced, California, United States
Stanford Cancer Institute Palo Alto
🇺🇸
Palo Alto, California, United States
Saint Helena Hospital
🇺🇸
Saint Helena, California, United States
Poudre Valley Hospital
🇺🇸
Fort Collins, Colorado, United States
North Colorado Medical Center
🇺🇸
Greeley, Colorado, United States
Hartford Hospital
🇺🇸
Hartford, Connecticut, United States
The Hospital of Central Connecticut
🇺🇸
New Britain, Connecticut, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
🇺🇸
Savannah, Georgia, United States
Radiation Oncology Associates PC
🇺🇸
Fort Wayne, Indiana, United States
Memorial Medical Center
🇺🇸
Springfield, Illinois, United States
Parkview Hospital Randallia
🇺🇸
Fort Wayne, Indiana, United States
Mercy Hospital
🇺🇸
Coon Rapids, Minnesota, United States
Harold Alfond Center for Cancer Care
🇺🇸
Augusta, Maine, United States
Siouxland Regional Cancer Center
🇺🇸
Sioux City, Iowa, United States
Maine Medical Center- Scarborough Campus
🇺🇸
Scarborough, Maine, United States
University of Maryland/Greenebaum Cancer Center
🇺🇸
Baltimore, Maryland, United States
Sinai Hospital of Baltimore
🇺🇸
Baltimore, Maryland, United States
Beaumont Hospital-Dearborn
🇺🇸
Dearborn, Michigan, United States
Lowell General Hospital
🇺🇸
Lowell, Massachusetts, United States
Mercy Health Saint Mary's
🇺🇸
Grand Rapids, Michigan, United States
West Michigan Cancer Center
🇺🇸
Kalamazoo, Michigan, United States
Saint Joseph Mercy Oakland
🇺🇸
Pontiac, Michigan, United States
Saint Mary's of Michigan
🇺🇸
Saginaw, Michigan, United States
Abbott-Northwestern Hospital
🇺🇸
Minneapolis, Minnesota, United States
Regions Hospital
🇺🇸
Saint Paul, Minnesota, United States
Rice Memorial Hospital
🇺🇸
Willmar, Minnesota, United States
Siteman Cancer Center at West County Hospital
🇺🇸
Creve Coeur, Missouri, United States
Washington University School of Medicine
🇺🇸
Saint Louis, Missouri, United States
Missouri Baptist Medical Center
🇺🇸
Saint Louis, Missouri, United States
Mercy Hospital Saint Louis
🇺🇸
Saint Louis, Missouri, United States
CoxHealth South Hospital
🇺🇸
Springfield, Missouri, United States
Concord Hospital
🇺🇸
Concord, New Hampshire, United States
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
🇺🇸
New Brunswick, New Jersey, United States
State University of New York Upstate Medical University
🇺🇸
Syracuse, New York, United States
Summa Barberton Hospital
🇺🇸
Barberton, Ohio, United States
North Coast Cancer Care
🇺🇸
Sandusky, Ohio, United States
Cleveland Clinic Cancer Center Strongsville
🇺🇸
Strongsville, Ohio, United States
Cleveland Clinic Wooster Family Health and Surgery Center
🇺🇸
Wooster, Ohio, United States
Natalie Warren Bryant Cancer Center at Saint Francis
🇺🇸
Tulsa, Oklahoma, United States
Salem Hospital
🇺🇸
Salem, Oregon, United States
Bryn Mawr Hospital
🇺🇸
Bryn Mawr, Pennsylvania, United States
Fox Chase Cancer Center
🇺🇸
Philadelphia, Pennsylvania, United States
Greenville Health System Cancer Institute-Greer
🇺🇸
Greer, South Carolina, United States
Greenville Health System Cancer Institute-Spartanburg
🇺🇸
Spartanburg, South Carolina, United States
Gibbs Cancer Center-Pelham
🇺🇸
Greer, South Carolina, United States
Greenville Health System Cancer Institute-Seneca
🇺🇸
Seneca, South Carolina, United States
The Don and Sybil Harrington Cancer Center
🇺🇸
Amarillo, Texas, United States
UT Southwestern/Simmons Cancer Center-Dallas
🇺🇸
Dallas, Texas, United States
M D Anderson Cancer Center
🇺🇸
Houston, Texas, United States
Covenant Medical Center-Lakeside
🇺🇸
Lubbock, Texas, United States
Dixie Medical Center Regional Cancer Center
🇺🇸
Saint George, Utah, United States
PeaceHealth Saint John Medical Center
🇺🇸
Longview, Washington, United States
Edwards Comprehensive Cancer Center
🇺🇸
Huntington, West Virginia, United States
Columbia Saint Mary's Water Tower Medical Commons
🇺🇸
Milwaukee, Wisconsin, United States
ProHealth Waukesha Memorial Hospital
🇺🇸
Waukesha, Wisconsin, United States
The Alyce and Elmore Kraemer Cancer Care Center
🇺🇸
West Bend, Wisconsin, United States
Dana-Farber Cancer Institute
🇺🇸
Boston, Massachusetts, United States
University of California Davis Comprehensive Cancer Center
🇺🇸
Sacramento, California, United States
Saint Joseph Mercy Hospital
🇺🇸
Ann Arbor, Michigan, United States
Wake Forest University Health Sciences
🇺🇸
Winston-Salem, North Carolina, United States
Mercy Cancer Center-Elyria
🇺🇸
Elyria, Ohio, United States
University of Chicago Comprehensive Cancer Center
🇺🇸
Chicago, Illinois, United States
Spartanburg Medical Center
🇺🇸
Spartanburg, South Carolina, United States
United Hospital
🇺🇸
Saint Paul, Minnesota, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
🇺🇸
Green Bay, Wisconsin, United States
UF Cancer Center at Orlando Health
🇺🇸
Orlando, Florida, United States
Saint Luke's Hospital of Kansas City
🇺🇸
Kansas City, Missouri, United States
Greenville Health System Cancer Institute-Faris
🇺🇸
Greenville, South Carolina, United States
Greenville Health System Cancer Institute-Eastside
🇺🇸
Greenville, South Carolina, United States
Rutgers Cancer Institute of New Jersey
🇺🇸
New Brunswick, New Jersey, United States
Tufts Medical Center
🇺🇸
Boston, Massachusetts, United States
Medical University of South Carolina
🇺🇸
Charleston, South Carolina, United States
Community Medical Center
🇺🇸
Toms River, New Jersey, United States
Community Memorial Hospital
🇺🇸
Menomonee Falls, Wisconsin, United States
Self Regional Healthcare
🇺🇸
Greenwood, South Carolina, United States
Banner MD Anderson Cancer Center
🇺🇸
Gilbert, Arizona, United States
Providence Saint Vincent Medical Center
🇺🇸
Portland, Oregon, United States
Beth Israel Deaconess Medical Center
🇺🇸
Boston, Massachusetts, United States
Legacy Good Samaritan Hospital and Medical Center
🇺🇸
Portland, Oregon, United States
Spectrum Health at Butterworth Campus
🇺🇸
Grand Rapids, Michigan, United States
Christiana Care Health System-Christiana Hospital
🇺🇸
Newark, Delaware, United States
Clackamas Radiation Oncology Center
🇺🇸
Clackamas, Oregon, United States
Saint Vincent Hospital Cancer Center Green Bay
🇺🇸
Green Bay, Wisconsin, United States
Virtua Voorhees
🇺🇸
Voorhees, New Jersey, United States
Kaiser Permanente Northwest
🇺🇸
Portland, Oregon, United States
Virtua Memorial
🇺🇸
Mount Holly, New Jersey, United States
Legacy Mount Hood Medical Center
🇺🇸
Gresham, Oregon, United States
Columbia Saint Mary's Hospital - Ozaukee
🇺🇸
Mequon, Wisconsin, United States
Froedtert and the Medical College of Wisconsin
🇺🇸
Milwaukee, Wisconsin, United States
Cancer Center of Western Wisconsin
🇺🇸
New Richmond, Wisconsin, United States
Northeast Georgia Medical Center-Gainesville
🇺🇸
Gainesville, Georgia, United States
Edward Hospital/Cancer Center
🇺🇸
Naperville, Illinois, United States