The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung
- Conditions
- Inhalation AnesthesiaLung Injury
- Interventions
- Registration Number
- NCT04645316
- Lead Sponsor
- Inonu University
- Brief Summary
Inhalation anesthesia; It means that the anesthetic drugs taken by the respiratory tract pass into the blood through the lung alveoli, reach the brain tissue, and create an anesthetic effect according to the density in the brain tissue. All inhalation anesthetics affect organ functions to varying degrees. Clara cell has been shown to have cell regeneration, immunomodulatory, anti-inflammatory and antioxidant activity in the bronchial epithelium. It is also thought that some substances accumulated in the respiratory system participate in the detoxification. Clara cell protein acts as a protein marker that indicates the severity of airway injuries after exposure to irritants. In this study, we planned to investigate the effect of inhalation anesthetics on Clara cell protein in liver transplant donors who will undergo hepatectomy surgery.
- Detailed Description
Inhalation anesthesia is still an important source of chemical hazard in the hospital environment due to its widespread use in operating rooms. Factors affecting the presence of anesthetic gases in the environment; device leakage, ventilation, fresh gas flow, and operation of the air cleaning system. Long-term exposure to anesthetic gases is known to adversely affect the health of employees in the operating room.
Clara cell plays a reliable role as a large bronchiolar progenitor cell that can contribute to cell regeneration in the bronchial epithelium. Thus, it contributes to the protection of the normal epithelium of the distal conductive airways. Additionally, it has been shown to have immunomodulatory, anti-inflammatory, and antioxidant activity. It is thought that some substances accumulated in the respiratory system participate in the detoxification.
Operations of patients undergoing hepatectomy usually take 4-6 hours. Inhalation anesthetics are widely used during this surgery. In this study, we thought to show the effect of long-term inhalation anesthesia exposure by performing this surgery on patients in this group. In this study, we aimed to investigate the effect of sevoflurane and desflurane inhalation anesthetics on clara cell protein in liver transplant donors scheduled for hepatectomy surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
- living liver donors
- smoking
- under 18 years
- over 65 years
- Patients who refused written informed consent forms
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sevoflurane Sevoflurane Sevoflurane will use for anesthesia maintenance for liver donor hepatectomy surgery Total intravenous anesthesia Propofol Total intravenous anesthesia (propofol/remifentanyl) will use for anesthesia maintenance for liver donor hepatectomy surgery Desflurane Desflurane Desflurane will use for anesthesia maintenance for liver donor hepatectomy surgery
- Primary Outcome Measures
Name Time Method clara cell protein blood levels baseline,up to 6 hours Hepatectomy surgery usually takes 4-6 hours. The clara cell protein levels (baseline) in the blood of the participants before surgery will be compared with the levels of clara cell protein in the blood that will be taken at the end of the surgery. The change between these levels will be measured by ELISA kit.
- Secondary Outcome Measures
Name Time Method mean arterial pressure Procedure (from beginning of anesthesia induction to extubation at 30-minute intervals) Mean arterial pressure will be measured at 30-minute intervals from the start of anesthesia induction to extubation.
Trial Locations
- Locations (1)
Inonu University
🇹🇷Malatya, Turkey