A Clinical Study of Subclinical Enthesitis and Synovitis in Patients With Vulgaris Psoriasis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of subclinical enthesitis and synovitis
研究概览
简要总结
A clinical study of subclinical enthesitis and synovitis in patients with vulgaris psoriasis
详细描述
A total of 100 patients with vulgaris psoriasis and 100 age-matched controls with other skin diseases, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded PDUS evaluation. Clinical assessment included demographics, severity of psoriasis, musculoskeletal clinical examination and sport activities. PDUS evaluation consisted of the detection of grey scale (GS) synovitis and synovial PD signal in joints of extremities, GS enthesopathy and entheseal PD signal in entheses of lower limbs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age≥18years
- •patients with vulgaris psoriasis(dur
- •patients with other skin diseases without musculoskeletal disorders
- •no joint involvement and no clinical symptoms and signs of enthesitis and synovitis
排除标准
- •have history of gout or arthritis or peripheral neurological disease of lower extremity or trauma
- •have received any systemic therapy(i.e.NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months
- •pregnant or breast-feeding
结局指标
主要结局
Incidence of subclinical enthesitis and synovitis
时间窗: one and a half year
To investigate the incidence of subclinical enthesitis and synovitis in patients with vulgaris
次要结局
- Number of participants with Risk factors of subclinical enthesitis and synovitis(one and a half year)