Effect of anesthesia technique on anti-tumor immunity
Not Applicable
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/09/036528
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 64
Inclusion Criteria
Patients undergoing surgery for Carcinoma Gall Bladder belonging to ASA class I,II and III
Exclusion Criteria
1. Patient refusal
2. Allergy to propofol or any study drugs
3. Chronic kidney or liver disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To detect the difference in post-operative serum TGF-β levels in patients receiving Propofol-based Total Intravenous Anesthesia versus inhalational based anesthesiaTimepoint: Pre-operative and 24 hours after surgery
- Secondary Outcome Measures
Name Time Method To compare incidence of post-operative complicationsTimepoint: up to 24 hours after surgery;To detect difference in peri-operative systemic inflammation and anti-tumor immunity: change between pre-operative and post-operative T-helper cell profile, IL-6, NLR, PLR, MLR and modified Glasgow prognostic scoreTimepoint: Pre-operative and 24 hours after surgery