Effects of anaesthetic technique on inflammatory stress response following laparoscopic hysterectomy in endometrial cancer patients: general anaesthesia combined with Transverse Abdominal Plane blockade (TAP) versus general anaesthesia and thoracic epidural analgesia (TEA).
Withdrawn
- Conditions
- endometrium cancerEndometrium carcinoma1003859410046828
- Registration Number
- NL-OMON43516
- Lead Sponsor
- Antoni van Leeuwenhoek Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
* Patients scheduled for elective laparoscopic hysterectomy, laparoscopic staging procedures, laparoscopic radical hysterectomy.
* Adult patients (older than 18 years of age)
* Written informed consent
* Understanding of Dutch or English language
Exclusion Criteria
* Non-elective surgery
* Any contraindication to neuraxial blockade (including coagulopathy, abnormal anatomy)
* Allergy to amide-linked local anaesthetics, especially bupivacaine
* Known psychiatric disorder
* Chronic pain patients or patients already using morphine pre-operatively
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Levels of cytokines (pro- and anti-inflammatory), procalcitonin, NLR and<br /><br>C-reactive protein</p><br>
- Secondary Outcome Measures
Name Time Method <p>1) Intensity of wound pain at rest and during movement by Numeric Rating Scale<br /><br>2) The number of milligrams of opioids and NSAID consumed by the patient.<br /><br>3) Health-related quality of life (HR-QOL) will be determined by EuroQol<br /><br>instrument (EQ-5D).<br /><br>4) Side effects such arrhythmias, hemodynamic changes and post epidural<br /><br>headache will be registered and recorded as absent or present.<br /><br>5) Length of hospital stay will be calculated and expressed in number of days. </p><br>