Effects of Anaesthesia On Immune Suppression, Inflammation AND Metastasis Of Breast Cancer.
Not Applicable
- Conditions
- Health Condition 1: C50- Malignant neoplasm of breast
- Registration Number
- CTRI/2020/11/028826
- Lead Sponsor
- Chittaranjan National Cancer Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Newly diagnosed breast cancer (Unilateral) confirmed with histopathological diagnosis. 2. ASA I (Normal healthy patient) & ASA II (Patient with mild systemic disease)
3. T1 N0, T2N0, T3N0, T1N1, T2N1, T3N1 Mx
4. Both male & female
6. Duration of surgery <= to 2 hrs.
Exclusion Criteria
1. Patient having any kind of anticancer treatment
2. Active bleeding
3. Recent history of massive blood transfusion
4. Pregnant & Lactating woman
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency and activity of NK cellsTimepoint: 1. Intra-operatively after 1 hour of incision. <br/ ><br>2. 48 hours post-operatively
- Secondary Outcome Measures
Name Time Method 1. Frequency of T-lymphocytes, B-lumphocytes. <br/ ><br>2. Expression of TNF-alpha, IL-6, IL- 8, IL-10, MMP-2, MMP-9.Timepoint: 1. Intra-operatively after 1 hour of incision. <br/ ><br>2. 48 hours post-operatively